{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:48:15Z","timestamp":1790999295810,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,10,16]],"date-time":"2021-10-16T00:00:00Z","timestamp":1634342400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003968","name":"Iran National Science Foundation","doi-asserted-by":"publisher","award":["92033574"],"award-info":[{"award-number":["92033574"]}],"id":[{"id":"10.13039\/501100003968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2021,10,16]]},"abstract":"<jats:p>Aim. The objectives of this study were to develop a new bioactive composite resin containing silver\/zinc oxide (Ag\/ZnO) nanoparticles and investigate the effects on mechanical, cytotoxic, biocompatibility, and antimicrobial properties. Materials and Methods. Disc-shaped specimens were prepared from composite with and without nanoparticles in separate culture media containing Streptococcus mutans, Lactobacillus, and Candida albicans. Bracket bonding evaluation was performed on composite without nanoparticles (O), composite containing ZnO (Z) nanoparticles, composite containing ZnO nanoparticles and silver ions (A&amp;Z), and composite containing Ag\/ZnO nanoparticles (AZ) synthesized using optical precipitation. Results. Composite resin with nanoparticles (AZ, A&amp;Z, and Z) showed significant antimicrobial properties (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                     <\/a:math>\n                  <\/jats:inline-formula>\u2009&lt;\u20090.05). The mean shear bond strength of A&amp;Z composite resin (13.61\u2009\u00b1\u20090.73\u2009MPa) was significantly less than that of conventional composite resin (19.03\u2009\u00b1\u20094.12\u2009MPa) (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                     <\/c:math>\n                  <\/jats:inline-formula>\u2009&lt;\u20090.05). In addition, the mean shear bond strength of AZ composite resin (20.49\u2009\u00b1\u20091.03\u2009MPa) was significantly higher than that of Z (16.35\u2009\u00b1\u20091.03\u2009MPa) and A&amp;Z composite resins. Conclusions. Incorporation of ZnO nanoparticles and their compounds into orthodontic composite resins induced antibacterial properties against oral pathogens, and of all these nanoparticles, the AZ group exhibited the best antimicrobial activity and highest shear bond strength.<\/jats:p>","DOI":"10.1155\/2021\/4743411","type":"journal-article","created":{"date-parts":[[2021,10,16]],"date-time":"2021-10-16T20:31:38Z","timestamp":1634416298000},"page":"1-8","source":"Crossref","is-referenced-by-count":26,"title":["A Novel Developed Bioactive Composite Resin Containing Silver\/Zinc Oxide (Ag\/ZnO) Nanoparticles as an Antimicrobial Material against Streptococcus mutans, Lactobacillus, and Candida albicans"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0054-5783","authenticated-orcid":true,"given":"Mojgan","family":"Kachoei","sequence":"first","affiliation":[{"name":"Department of Orthodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran"},{"name":"Dental and Periodontal Research Center, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8367-6430","authenticated-orcid":true,"given":"Baharak","family":"Divband","sequence":"additional","affiliation":[{"name":"Dental and Periodontal Research Center, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran"},{"name":"Department of Inorganic Chemistry, Faculty of Chemistry, University of Tabriz, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9049-8169","authenticated-orcid":true,"given":"Mahdi","family":"Rahbar","sequence":"additional","affiliation":[{"name":"Department of Esthetic and Restorative Dentistry, School of Dentistry, Ardabil University of Medical Sciences, Ardabil, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2718-5995","authenticated-orcid":true,"given":"Mahdiyeh","family":"Esmaeilzadeh","sequence":"additional","affiliation":[{"name":"Student Research Committee, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0251-8228","authenticated-orcid":true,"given":"Milad","family":"Ghanizadeh","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3827-9708","authenticated-orcid":true,"given":"Mostafa","family":"Alam","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.4103\/ccd.ccd_2_18"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1186\/s40510-016-0153-x"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.15171\/jlms.2018.32"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1038\/srep36383"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.5812\/ajdr.60720"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1039\/b715532h"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.3109\/00016357.2013.859728"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.5812\/jjm.11680"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2013.03.011"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.dental.2008.06.002"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1080\/15376516.2019.1566424"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2016-0171"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.15171\/joddd.2016.014"},{"issue":"2","key":"14","first-page":"28","article-title":"Evaluation of the effect of fluoride gel and varnish on the demineralization resistance of enamel: an in vitro","volume":"24","author":"S. Tavassoli-Hojjati","year":"2012","journal-title":"Journal of Islamic Dental Association of IRAN"},{"issue":"4","key":"15","doi-asserted-by":"crossref","first-page":"219","DOI":"10.15171\/bi.2016.29","article-title":"Lactobacillus L. species mediated synthesis of silver nanoparticles and their antibacterial activity against opportunistic pathogens","volume":"6","author":"I. Garmasheva","year":"2016","journal-title":"In Vitro Bioimpacts"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2003.10.078"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjs073"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.3390\/nano10081466"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1186\/s40563-016-0065-5"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1590\/1678-775720140496"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1590\/2177-6709.22.5.067-074.oar"},{"issue":"1","key":"22","doi-asserted-by":"crossref","first-page":"42","DOI":"10.21307\/aoj-2020-139","article-title":"An evaluation of the antibacterial properties and shear bond strength of copper nanoparticles as a nanofiller in orthodontic adhesive","volume":"31","author":"L. Argueta-Figueroa","year":"2015","journal-title":"Australian Orthodontic Journal"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2021\/4743411.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2021\/4743411.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2021\/4743411.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,16]],"date-time":"2021-10-16T20:31:57Z","timestamp":1634416317000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ecam\/2021\/4743411\/"}},"subtitle":[],"editor":[{"given":"Mohsen","family":"Yazdanian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,10,16]]},"references-count":22,"alternative-id":["4743411","4743411"],"URL":"https:\/\/doi.org\/10.1155\/2021\/4743411","relation":{},"ISSN":["1741-4288","1741-427X"],"issn-type":[{"value":"1741-4288","type":"electronic"},{"value":"1741-427X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10,16]]}}}