{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:31:21Z","timestamp":1792654281389,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T00:00:00Z","timestamp":1629849600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006378","name":"Universitas Indonesia","doi-asserted-by":"publisher","award":["15\/SP2H\/DRPM\/LPPM-UNJ\/2018"],"award-info":[{"award-number":["15\/SP2H\/DRPM\/LPPM-UNJ\/2018"]}],"id":[{"id":"10.13039\/501100006378","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Research, Technology and Higher Education","award":["15\/SP2H\/DRPM\/LPPM-UNJ\/2018"],"award-info":[{"award-number":["15\/SP2H\/DRPM\/LPPM-UNJ\/2018"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Scientifica"],"published-print":{"date-parts":[[2021,8,25]]},"abstract":"<jats:p>Delayed union and nonunion fractures are clinical challenges for orthopedic surgeons. The development of fracture complications, such as delayed union and nonunion fractures, is still difficult to predict. Various methods are being investigated to improve fracture healing and prevent complications in patients. There are various methods to promote fracture healing, broadly divided into biological, chemical, and physical methods. One of the most widely used physical methods to promote fracture healing is the pulsed electromagnetic field (PEMF). This study aimed to evaluate the healing process of delayed union fracture after being stimulated by PEMF. Twenty-four rats were randomly divided into two groups: the control group (n\u2009=\u200912) and the PEMF group (n\u2009=\u200912). Delayed union fracture was performed on the left femur of all rats. Subsequently, the PEMF group was given PEMF stimulus with a magnetic field intensity of 1.6\u2009mT and a frequency of 50\u2009Hz for 4 hours\/day and 7 days\/week. The fracture healing process was evaluated on days 5, 10, 18, and 28 based on the bone callus histology using safranin O fast green (SOFG) staining. The results of the histological analysis showed that bone cartilage was higher in the PEMF group than in the control group throughout the observation period. In addition, the PEMF group had less fibrous tissue at the beginning of the healing. This finding indicates PEMF stimulation has an effect on inducing osteogenesis on fracture healing and reducing the risk of delayed union.<\/jats:p>","DOI":"10.1155\/2021\/4791172","type":"journal-article","created":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T16:07:01Z","timestamp":1629994021000},"page":"1-6","source":"Crossref","is-referenced-by-count":9,"title":["Histological Analysis of Bone Callus in Delayed Union Model Fracture Healing Stimulated with Pulsed Electromagnetic Fields (PEMF)"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4860-0801","authenticated-orcid":true,"given":"U.","family":"Umiatin","sequence":"first","affiliation":[{"name":"Department of Physics, Faculty of Mathematics and Natural Science, State University of Jakarta, Jakarta, Indonesia"},{"name":"Doctoral Program in Biomedical Science, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6202-0918","authenticated-orcid":true,"given":"Ismail","family":"Hadisoebroto Dilogo","sequence":"additional","affiliation":[{"name":"Department of Orthopedic and Traumatology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puji","family":"Sari","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sastra","family":"Kusuma Wijaya","sequence":"additional","affiliation":[{"name":"Department of Physics, Faculty of Mathematics and Natural Science, University of Indonesia, Depok, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.11138\/ccmbm\/2016.13.2.101"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-0266(02)00209-7"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1186\/1749-799X-7-24"},{"key":"4","first-page":"23","article-title":"Biophysical stimulation of the knee with PEMFs: From bench to bedside","volume":"32","author":"G. 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Sari","year":"2019","journal-title":"Journal of Global Pharma Technology"}],"container-title":["Scientifica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/scientifica\/2021\/4791172.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/scientifica\/2021\/4791172.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/scientifica\/2021\/4791172.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,26]],"date-time":"2021-08-26T16:07:07Z","timestamp":1629994027000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/scientifica\/2021\/4791172\/"}},"subtitle":[],"editor":[{"given":"Huaxin","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,8,25]]},"references-count":23,"alternative-id":["4791172","4791172"],"URL":"https:\/\/doi.org\/10.1155\/2021\/4791172","relation":{},"ISSN":["2090-908X"],"issn-type":[{"value":"2090-908X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,25]]}}}