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The cases also highlight the diversity and variability that cover a patient\u2019s journey that is highly dependent on accessibility based on financial capability and social support. The clinical presentation is more aggressive due to the higher tumour burden and more proliferative tumor cells with cytopenias being profound and more organomegaly. The diagnosis is made based on at least 20% of total white blood cells being circulating plasma cells with a peripheral blood absolute plasma cell count of at least 2\u2009\u00d7\u2009109\/l. Treatment with novel agents followed by autologous stem cell transplant in those who are transplant eligible leads to better outcomes.<\/jats:p>","DOI":"10.1155\/2021\/4843818","type":"journal-article","created":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T19:20:08Z","timestamp":1627413608000},"page":"1-6","source":"Crossref","is-referenced-by-count":1,"title":["Plasma Cell Leukemia: A Review of 3 Cases Managed in Kenya"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8386-4802","authenticated-orcid":true,"given":"Matilda","family":"Ong\u2019ondi","sequence":"first","affiliation":[{"name":"Department of Internal Medicine; Hemato-oncology Unit, Kenyatta National Hospital, Nairobi, Kenya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Kagotho","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Aga Khan University hospital, Nairobi, Kenya"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-019-0754-x"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2009.27.15_suppl.8605"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-282632"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.2147\/clep.s99463"},{"issue":"2","key":"5","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/s12032-007-9011-5","article-title":"Thirty patients with primary plasma cell leukemia: a single center experience","volume":"25","author":"M. \u010colovi\u0107","year":"2008","journal-title":"Medical Oncology"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq646"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1007\/bf02671298"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1159\/000210555"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.336"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/s0145-2126(00)00102-8"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1007\/s12288-019-01114-9"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.133.5.813"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1080\/10428190802290660"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.4081\/rt.2012.e39"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2008.4"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23600"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15092"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.2991\/chi.k.200706.002"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22700"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2011.06.010"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2011.312"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1080\/10428190601007570"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1080\/10428190701361851"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.013334"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.2339"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12986"},{"issue":"2","key":"27","first-page":"91","article-title":"Bortezomib-based regimens improve the outcome of patients with primary or secondary plasma cell leukemia: a retrospective cohort study","volume":"37","author":"H. Wang","year":"2020","journal-title":"Turkish Journal of Hematology"}],"container-title":["Case Reports in Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2021\/4843818.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2021\/4843818.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2021\/4843818.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T08:57:18Z","timestamp":1628845038000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crihem\/2021\/4843818\/"}},"subtitle":[],"editor":[{"given":"Pier Paolo","family":"Piccaluga","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,7,27]]},"references-count":27,"alternative-id":["4843818","4843818"],"URL":"https:\/\/doi.org\/10.1155\/2021\/4843818","relation":{},"ISSN":["2090-6579","2090-6560"],"issn-type":[{"type":"electronic","value":"2090-6579"},{"type":"print","value":"2090-6560"}],"subject":[],"published":{"date-parts":[[2021,7,27]]}}}