{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T21:53:49Z","timestamp":1793051629664,"version":"4.5.0"},"reference-count":173,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T00:00:00Z","timestamp":1630886400000},"content-version":"vor","delay-in-days":248,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1201039"],"award-info":[{"award-number":["1201039"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1200944"],"award-info":[{"award-number":["1200944"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Bile acids (BA) are recognized by their role in nutrient absorption. However, there is growing evidence that BA also have endocrine and metabolic functions. Besides, the steroidal\u2010derived structure gives BA a toxic potential over the biological membrane. Thus, cholestatic disorders, characterized by elevated BA on the liver and serum, are a significant cause of liver transplant and extrahepatic complications, such as skeletal muscle, central nervous system (CNS), heart, and placenta. Further, the BA have an essential role in cellular damage, mediating processes such as membrane disruption, mitochondrial dysfunction, and the generation of reactive oxygen species (ROS) and oxidative stress. The purpose of this review is to describe the BA and their role on hepatic and extrahepatic complications in cholestatic diseases, focusing on the association between BA and the generation of oxidative stress that mediates tissue damage.<\/jats:p>","DOI":"10.1155\/2021\/4847941","type":"journal-article","created":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T17:47:32Z","timestamp":1630950452000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Redox\u2010Dependent Effects in the Physiopathological Role of Bile Acids"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0006-1298","authenticated-orcid":false,"given":"Josu\u00e9","family":"Orozco-Aguilar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2653-9798","authenticated-orcid":false,"given":"Felipe","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7273-2102","authenticated-orcid":false,"given":"Claudio","family":"Cabello-Verrugio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,6]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/164_2019_238"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2018.1424538"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2012.07.004"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom8040159"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/1756284818787400"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v12.i8.423"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00049.2019"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.3727\/105221618X15156018385515"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2019.104595"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/glia.21049"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2015.10.005"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/1201624"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c120023"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.5604\/01.3001.0010.5493"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R500013-JLR200"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2015.1127483"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.12.040"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00223.2019"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5418.1365"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80348-2"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5418.1362"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M209505200"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.3.864-872.2003"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)00051-4"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M105117200"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI42846"},{"key":"e_1_2_11_27_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.25503"},{"key":"e_1_2_11_28_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M011610200"},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109326200"},{"key":"e_1_2_11_30_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00539.2005"},{"key":"e_1_2_11_31_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M207903200"},{"key":"e_1_2_11_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00062-3"},{"key":"e_1_2_11_33_2","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.32.172"},{"key":"e_1_2_11_34_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M209525200"},{"key":"e_1_2_11_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28890"},{"key":"e_1_2_11_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2020.108033"},{"key":"e_1_2_11_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2018.08.016"},{"key":"e_1_2_11_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-020-01652-z"},{"key":"e_1_2_11_39_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9010060"},{"key":"e_1_2_11_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)02550-0"},{"key":"e_1_2_11_41_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M209706200"},{"key":"e_1_2_11_42_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00383.2012"},{"key":"e_1_2_11_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04330"},{"key":"e_1_2_11_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29839"},{"key":"e_1_2_11_45_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.002733"},{"key":"e_1_2_11_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-25569-4"},{"key":"e_1_2_11_47_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00646"},{"key":"e_1_2_11_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24525"},{"key":"e_1_2_11_49_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.113.301565"},{"key":"e_1_2_11_50_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI76289"},{"key":"e_1_2_11_51_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.09.055"},{"key":"e_1_2_11_52_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00400.2012"},{"key":"e_1_2_11_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.07.002"},{"key":"e_1_2_11_54_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21217922"},{"key":"e_1_2_11_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2011.09.003"},{"key":"e_1_2_11_56_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24681"},{"key":"e_1_2_11_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2013.06.011"},{"key":"e_1_2_11_58_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-11-467191"},{"key":"e_1_2_11_59_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.668277"},{"key":"e_1_2_11_60_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27592"},{"key":"e_1_2_11_61_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.051551698"},{"key":"e_1_2_11_62_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.846800"},{"key":"e_1_2_11_63_2","doi-asserted-by":"publisher","DOI":"10.1007\/164_2019_236"},{"key":"e_1_2_11_64_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.051014398"},{"key":"e_1_2_11_65_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20784"},{"key":"e_1_2_11_66_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0409794102"},{"key":"e_1_2_11_67_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1070477"},{"key":"e_1_2_11_68_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M411520200"},{"key":"e_1_2_11_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2015.02.005"},{"key":"e_1_2_11_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.06.049"},{"key":"e_1_2_11_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2019.09.002"},{"key":"e_1_2_11_72_2","doi-asserted-by":"publisher","DOI":"10.1007\/164_2019_230"},{"key":"e_1_2_11_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2014.12.009"},{"key":"e_1_2_11_74_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03401914"},{"key":"e_1_2_11_75_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1325"},{"key":"e_1_2_11_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.02.028"},{"key":"e_1_2_11_77_2","first-page":"1595","article-title":"Toxicity of bile acids on the electron transport chain of isolated rat liver mitochondria","volume":"20","author":"Krahenbul S.","year":"1994","journal-title":"Hepatology"},{"key":"e_1_2_11_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(00)00259-8"},{"key":"e_1_2_11_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2010.11.026"},{"key":"e_1_2_11_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2017.06.001"},{"key":"e_1_2_11_81_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI4765"},{"key":"e_1_2_11_82_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20130642"},{"key":"e_1_2_11_83_2","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfh078"},{"key":"e_1_2_11_84_2","doi-asserted-by":"publisher","DOI":"10.1385\/CT:5:1:063"},{"key":"e_1_2_11_85_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.22702"},{"key":"e_1_2_11_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2004.10.020"},{"key":"e_1_2_11_87_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs011"},{"key":"e_1_2_11_88_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-011-0633-x"},{"key":"e_1_2_11_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90585-5"},{"key":"e_1_2_11_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2017.12.039"},{"key":"e_1_2_11_91_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.32976"},{"key":"e_1_2_11_92_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4400560"},{"key":"e_1_2_11_93_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200204000-00010"},{"key":"e_1_2_11_94_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.104.070532"},{"key":"e_1_2_11_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2019.146566"},{"key":"e_1_2_11_96_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00193"},{"key":"e_1_2_11_97_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/956792"},{"key":"e_1_2_11_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101284"},{"key":"e_1_2_11_99_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2014.09.010"},{"key":"e_1_2_11_100_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2015.04.062"},{"key":"e_1_2_11_101_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2015.01.002"},{"key":"e_1_2_11_102_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.06.010"},{"key":"e_1_2_11_103_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/761264"},{"key":"e_1_2_11_104_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/1617805"},{"key":"e_1_2_11_105_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840170518"},{"key":"e_1_2_11_106_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10713"},{"key":"e_1_2_11_107_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-018-2167-3"},{"key":"e_1_2_11_108_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/2063179"},{"key":"e_1_2_11_109_2","doi-asserted-by":"publisher","DOI":"10.2174\/1566524019666190917124636"},{"key":"e_1_2_11_110_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2008.09.002"},{"key":"e_1_2_11_111_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2009.01.014"},{"key":"e_1_2_11_112_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00261.2018"},{"key":"e_1_2_11_113_2","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2021.1900593"},{"key":"e_1_2_11_114_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201600275R"},{"key":"e_1_2_11_115_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2018.04.003"},{"key":"e_1_2_11_116_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2014.01.159"},{"key":"e_1_2_11_117_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.07.217"},{"key":"e_1_2_11_118_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2011.11.036"},{"key":"e_1_2_11_119_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112212"},{"key":"e_1_2_11_120_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-01838-w"},{"key":"e_1_2_11_121_2","doi-asserted-by":"publisher","DOI":"10.1159\/000494139"},{"key":"e_1_2_11_122_2","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2019.1587293"},{"key":"e_1_2_11_123_2","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12438"},{"key":"e_1_2_11_124_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2019.05.022"},{"key":"e_1_2_11_125_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6372786"},{"key":"e_1_2_11_126_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-40002-0"},{"key":"e_1_2_11_127_2","article-title":"Overexpression of TGR5 alleviates myocardial ischemia\/reperfusion injury via AKT\/GSK-3\u03b2 mediated inflammation and mitochondrial pathway","volume":"40","author":"Li J.","year":"2020","journal-title":"Bioscience Reports"},{"key":"e_1_2_11_128_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2020.10.014"},{"key":"e_1_2_11_129_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2015.12.008"},{"key":"e_1_2_11_130_2","doi-asserted-by":"publisher","DOI":"10.1053\/he.2000.5921"},{"key":"e_1_2_11_131_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2014.03.023"},{"key":"e_1_2_11_132_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-013-2995-5"},{"key":"e_1_2_11_133_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31270-X"},{"key":"e_1_2_11_134_2","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.16567"},{"key":"e_1_2_11_135_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-010-9202-6"},{"key":"e_1_2_11_136_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.12.034"},{"key":"e_1_2_11_137_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm0002127"},{"key":"e_1_2_11_138_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-38668-7"},{"key":"e_1_2_11_139_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c01065"},{"key":"e_1_2_11_140_2","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2018.1459569"},{"key":"e_1_2_11_141_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.01.139"},{"key":"e_1_2_11_142_2","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13080"},{"key":"e_1_2_11_143_2","doi-asserted-by":"publisher","DOI":"10.1039\/C7RA04922F"},{"key":"e_1_2_11_144_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm401873d"},{"key":"e_1_2_11_145_2","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12636"},{"key":"e_1_2_11_146_2","unstructured":"Kythera BiopharmaceuticalsI. Kybella\u2122 2015 https:\/\/www.accessdata.fda.gov\/scripts\/cder\/daf\/."},{"key":"e_1_2_11_147_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1037"},{"key":"e_1_2_11_148_2","doi-asserted-by":"publisher","DOI":"10.2337\/db10-0308"},{"key":"e_1_2_11_149_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112731"},{"key":"e_1_2_11_150_2","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13140"},{"key":"e_1_2_11_151_2","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12648"},{"key":"e_1_2_11_152_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1916945"},{"key":"e_1_2_11_153_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27091"},{"key":"e_1_2_11_154_2","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12999"},{"key":"e_1_2_11_155_2","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15967"},{"key":"e_1_2_11_156_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61933-4"},{"key":"e_1_2_11_157_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30184-0"},{"key":"e_1_2_11_158_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.05.042"},{"key":"e_1_2_11_159_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(19)30094-9"},{"key":"e_1_2_11_160_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29569"},{"key":"e_1_2_11_161_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.05.009"},{"key":"e_1_2_11_162_2","doi-asserted-by":"publisher","DOI":"10.1210\/me.2010-0460"},{"key":"e_1_2_11_163_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.113.210005"},{"key":"e_1_2_11_164_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm500829b"},{"key":"e_1_2_11_165_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.06.011"},{"key":"e_1_2_11_166_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.156"},{"key":"e_1_2_11_167_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27074"},{"key":"e_1_2_11_168_2","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.1965"},{"key":"e_1_2_11_169_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-88493-0"},{"key":"e_1_2_11_170_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2017020222"},{"key":"e_1_2_11_171_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C117.794982"},{"key":"e_1_2_11_172_2","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S170518"},{"key":"e_1_2_11_173_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i2.195"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2021\/4847941.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2021\/4847941.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2021\/4847941","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T18:54:53Z","timestamp":1723056893000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/4847941"}},"subtitle":[],"editor":[{"given":"Anwen","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":173,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1155\/2021\/4847941"],"URL":"https:\/\/doi.org\/10.1155\/2021\/4847941","archive":["Portico"],"relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"2021-05-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"4847941"}}