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In recent years, several nutraceutical interventions have been investigated in order to define better solutions for preventing and treating OA. Among them, polyunsaturated fatty acids (n\u20103 PUFAs) appear to represent potential candidates in counteracting OA and its consequences, due to their anti\u2010inflammatory, antioxidant, and chondroinductive effects. PUFAs have been found to counteract the onset and progression of OA by reducing bone and cartilage destruction, inhibiting proinflammatory cytokine release, reactive oxygen species (ROS) generation, and the NF\u2010<jats:italic>\u03ba<\/jats:italic>B pathway\u2019s activation. Moreover, a diet rich in n\u20103 PUFAs and their derivatives (maresins and resolvins) demonstrates beneficial effects on associated pain reduction. Finally, it has been shown that together with the anti\u2010inflammatory and antioxidant properties of eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids, their antiapoptotic and antiangiogenic effects contribute in reducing OA development. The present review is aimed at assessing evidence suggesting the potential benefit of nutraceutical supplementation with PUFAs in OA management according to their efficacy in targeting relevant pathophysiological mechanisms responsible for inflammation and joint destruction processes, and this may represent a novel and potentially useful approach in OA prevention and treatment. For that purpose, a PubMed literature survey was conducted with a focus on some in vitro and in vivo studies and clinical trials from 2015 to 2020.<\/jats:p>","DOI":"10.1155\/2021\/4878562","type":"journal-article","created":{"date-parts":[[2021,12,10]],"date-time":"2021-12-10T21:35:12Z","timestamp":1639172112000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The Role of Nutraceuticals in Osteoarthritis Prevention and Treatment: Focus on n\u20103 PUFAs"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0930-8987","authenticated-orcid":false,"given":"Francesca","family":"Oppedisano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa 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