{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T13:25:28Z","timestamp":1775309128795,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T00:00:00Z","timestamp":1639612800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012899","name":"Lanzhou University","doi-asserted-by":"publisher","award":["CY2019-MS04"],"award-info":[{"award-number":["CY2019-MS04"]}],"id":[{"id":"10.13039\/100012899","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2021,12,16]]},"abstract":"<jats:p>Accumulating studies revealed association between development of glioma and miRNA dysregulation. A case in point is miR-381-3p, but its mechanism in glioma is unclear yet. In this work, we confirmed that overexpressed miR-381-3p repressed biological functions of glioma cells. Additionally, we also discovered that upregulated anthrax toxin receptor 1 (ANTXR1) was negatively mediated by miR-381-3p. We further proved that miR-381-3p-targeted ANTXR1 was able to counteract the suppression of miR-381-3p on biological functions of glioma. We concluded that miR-381-3p and ANTXR1 were both important factors in modulating glioma progression. miR-381-3p\/ANTXR1 axis is expected to be a molecular target for glioma.<\/jats:p>","DOI":"10.1155\/2021\/4883509","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T20:05:05Z","timestamp":1639685105000},"page":"1-7","source":"Crossref","is-referenced-by-count":4,"title":["miR-381-3p Involves in Glioma Progression by Suppressing Tumor-Promoter Factor ANTXR1"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1094-5580","authenticated-orcid":true,"given":"Zhiqiang","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Lanzhou University Second Hospital, Lanzhou University Second Clinical Medical College, Lanzhou 730030, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5241-9327","authenticated-orcid":true,"given":"Jinglong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Lanzhou University Second Hospital, Lanzhou University Second Clinical Medical College, Lanzhou 730030, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0755-3631","authenticated-orcid":true,"given":"Liang","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Lanzhou University Second Hospital, Lanzhou University Second Clinical Medical College, Lanzhou 730030, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1951-3848","authenticated-orcid":true,"given":"Guokuo","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Lanzhou University Second Hospital, Lanzhou University Second Clinical Medical College, Lanzhou 730030, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1005-3846","authenticated-orcid":true,"given":"Zhenshan","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Lanzhou University Second Hospital, Lanzhou University Second Clinical Medical College, Lanzhou 730030, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0432-2141","authenticated-orcid":true,"given":"Qiang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Lanzhou University Second Hospital, Lanzhou University Second Clinical Medical College, Lanzhou 730030, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noy131"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/64.6.479"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-03247-6"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2020.02.002"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1080\/14728214.2016.1257609"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.2165\/00063030-200923010-00003"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14981"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S222836"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_201806_15264"},{"issue":"4","key":"10","first-page":"913","article-title":"miR-381-3p suppresses the proliferation of oral squamous cell carcinoma cells by directly targeting FGFR2","volume":"7","author":"X. 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