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The combination of big data and medical information produces the emerging field of WITMED (Wise Information Technology of Med). WITMED is essential for the prospering growth of smart cities, which assumed a high quality of medical service is the most challenging goal for the city government. In this paper, the main attention is paid to the method of targeted gene therapy, which provides a new method for the treatment of oral cancer in inhibiting the growth, differentiation, invasion, and metastasis of oral cancer cells; therefore, the physical and psychological adverse effects of surgery and chemotherapy on patients are reduced and the survival and prognosis of patients are improved. Targeted gene therapy methods need to select the appropriate gene; that is, data mining methods are used to analyze a large number of complex genetic data from smart cities to obtain appropriate genetic markers, which makes the effect of targeted gene therapy better, and also provide some reference for the research of oral cancer gene direction and provide some basis for clinical treatment.<\/jats:p>","DOI":"10.1155\/2021\/4907687","type":"journal-article","created":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T20:05:12Z","timestamp":1639857912000},"page":"1-12","source":"Crossref","is-referenced-by-count":0,"title":["Application of Data Mining in WITMED: Identification of Prognostic Genes in Oral Cancer"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7139-0462","authenticated-orcid":true,"given":"Gang","family":"Liu","sequence":"first","affiliation":[{"name":"School of Information Science & Engineering, LanZhou University, LanZhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Information Science & Engineering, LanZhou University, LanZhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"He","family":"Qin","sequence":"additional","affiliation":[{"name":"School of Information Science & Engineering, LanZhou University, LanZhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingguo","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Information Science & Engineering, LanZhou University, LanZhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianbing","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Computer Science, ChengDu University of Information Technology, ChengDu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaokang","family":"Zhou","sequence":"additional","affiliation":[{"name":"The Faculty of Data Science, Shiga University, Tokyo, Japan"},{"name":"RIKEN Center for Advanced Intelligence Project, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9898-0814","authenticated-orcid":true,"given":"Haiyan","family":"Zhen","sequence":"additional","affiliation":[{"name":"The First Hospital of Lanzhou University, LanZhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","first-page":"50","article-title":"The Concept of Smart City and Future City Development","volume":"17","author":"W. 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