{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:02:37Z","timestamp":1788134557798,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T00:00:00Z","timestamp":1640908800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2021,12,31]]},"abstract":"<jats:p>Background. Ranolazine is a second-line drug for the management of chronic coronary syndromes (CCS). Glucose-lowering and endothelial effects have also been reported with this agent. However, whether ranolazine may improve short-term glycemic variability (GV), strictly related to the prognosis of patients with type 2 diabetes (T2D), is unknown. Thus, we aimed to explore the effects of adding ranolazine to standard anti-ischemic and glucose-lowering therapy on long- and short-term GV as well as on endothelial function and oxidative stress in patients with T2D and CCS. Methods. Patients starting ranolazine (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>n<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>16<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>) were evaluated for short-term GV, haemoglobin 1Ac (Hb1Ac) levels, endothelial-dependent flow-mediated vasodilation (FMD), and oxidative stress levels at enrolment and after 3-month follow-up. The same measurements were collected from 16 patients with CCS and T2D that did not receive ranolazine, matched for age, gender, and body mass index. Results. A significant decline in Hb1Ac levels was reported after 3-month ranolazine treatment (mean change -0.60%; 2-way ANOVA <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.025<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). Moreover, among patients receiving ranolazine, short-term GV indexes were significantly improved over time compared with baseline (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>p<\/e:mi>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>0.001<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula> for time in range; 2-way ANOVA <jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>p<\/g:mi>\n                        <g:mo>=<\/g:mo>\n                        <g:mn>0.010<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>). Conversely, no significant changes were reported in patients without ranolazine. Finally, greater FMD and lower oxidative stress levels were observed in patients on ranolazine at 3 months. Conclusions. Ranolazine added to standard anti-ischemic and glucose-lowering therapy demonstrated benefit in improving the glycemic status of patients with T2D and CCS. How this improvement contributes to the overall myocardial benefit of ranolazine requires further studies.<\/jats:p>","DOI":"10.1155\/2021\/4952447","type":"journal-article","created":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T22:20:41Z","timestamp":1640989241000},"page":"1-9","source":"Crossref","is-referenced-by-count":11,"title":["Ranolazine Improves Glycemic Variability and Endothelial Function in Patients with Diabetes and Chronic Coronary Syndromes: Results from an Experimental Study"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5616-3197","authenticated-orcid":true,"given":"Annunziata","family":"Nusca","sequence":"first","affiliation":[{"name":"Unit of Cardiac Sciences, Department of Medicine, Campus Bio-Medico University of Rome, Via Alvaro del Portillo 200, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Bernardini","sequence":"additional","affiliation":[{"name":"Unit of Cardiac Sciences, Department of Medicine, Campus Bio-Medico University of Rome, Via Alvaro del Portillo 200, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Mangiacapra","sequence":"additional","affiliation":[{"name":"Unit of Cardiac Sciences, Department of Medicine, Campus Bio-Medico University of Rome, Via Alvaro del Portillo 200, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Maddaloni","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosetta","family":"Melfi","sequence":"additional","affiliation":[{"name":"Unit of Cardiac Sciences, Department of Medicine, Campus Bio-Medico University of Rome, Via Alvaro del Portillo 200, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Ricottini","sequence":"additional","affiliation":[{"name":"Unit of Cardiac Sciences, Department of Medicine, Campus Bio-Medico University of Rome, Via Alvaro del Portillo 200, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Piccirillo","sequence":"additional","affiliation":[{"name":"Unit of Cardiac Sciences, Department of Medicine, Campus Bio-Medico University of Rome, Via Alvaro del Portillo 200, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Manfrini","sequence":"additional","affiliation":[{"name":"Unit of Endocrinology and Diabetes, Department of Medicine, Campus Bio-Medico University of Rome, Via Alvaro del Portillo 200, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Paolo","family":"Ussia","sequence":"additional","affiliation":[{"name":"Unit of Cardiac Sciences, Department of Medicine, Campus Bio-Medico University of Rome, Via Alvaro del Portillo 200, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Grigioni","sequence":"additional","affiliation":[{"name":"Unit of Cardiac Sciences, Department of Medicine, Campus Bio-Medico University of Rome, Via Alvaro del Portillo 200, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2008.03.019"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz425"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.2337\/db13-1562"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi495"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-2334"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-2629"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3047"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-1459"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-020-01134-0"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-019-0952-8"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.2337\/dci19-0028"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz350"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.3109\/10715762.2014.919390"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2004.016"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.5551\/jat.e265"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.7754\/Clin.Lab.2013.121022"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.763912"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.2337\/db11-868-1281"},{"issue":"5","key":"19","first-page":"44","article-title":"The effects of ranolazine on hemoglobin A1c in a veteran population","volume":"35","author":"L. 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