{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T16:37:58Z","timestamp":1780072678374,"version":"3.54.0"},"reference-count":19,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T00:00:00Z","timestamp":1636416000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2021,11,9]]},"abstract":"<jats:p>Objective. To explore the diagnostic value of serum heparin binding protein (HBP), blood lactic acid (Lac) combined with high-sensitivity C- reactive protein (hs-CRP) in sepsis and its relationship with prognosis. Methods. The clinical data of 127 patients with sepsis from March 2019 to March 2021 in our hospital were retrospectively analyzed. 120 outpatients undergoing physical examination in the same period in our hospital were selected as the control group. According to the severity of the disease, 127 sepsis patients were divided into the mild sepsis group (n\u2009=\u200945), severe sepsis group (n\u2009=\u200953), and septic shock group (n\u2009=\u200929). According to the clinical prognosis, the patients were divided into the survival group (n\u2009=\u200996) and death group (n\u2009=\u200931). Serum HBP, Lac, and hs-CRP levels were measured in all subjects. The ROC curves of the subjects were drawn to analyze the predictive value of serum HBP, Lac, and hs-CRP for the prognosis of sepsis patients. Results. The levels of serum HBP, Lac, and hs-CRP in the sepsis group were higher than those in the control group (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). With the increase of the severity of sepsis, serum HBP, Lac, and hs-CRP levels of patients gradually increased (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). The levels of serum HBP, Lac, and hs-CRP in the death group were higher than those in the survival group (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.05<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>). The AUC of serum HBP, Lac, and hs-CRP for predicting the prognosis of sepsis patients was 0.858 (95% CI: 0.763\u20130.953), 0.694 (95% CI: 0.589\u20130.799), and 0.843 (95% CI: 0.759\u20130.927). The AUC of serum HBP, Lac combined with hs-CRP for predicting the prognosis of sepsis patients was 0.961 (95% CI: 0.000\u20131.000). Conclusion. The levels of serum HBP, Lac, and hs-CRP in patients with sepsis were significantly increased and increased with the severity of sepsis. Serum HBP, Lac, and hs-CRP have a good value in predicting the prognosis of patients with sepsis and worthy of clinical application.<\/jats:p>","DOI":"10.1155\/2021\/5023733","type":"journal-article","created":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T22:50:07Z","timestamp":1636498207000},"page":"1-6","source":"Crossref","is-referenced-by-count":8,"title":["Diagnostic Value of Serum Heparin Binding Protein, Blood Lactic Acid Combined with hs-CRP in Sepsis and Its Relationship with Prognosis"],"prefix":"10.1155","volume":"2021","author":[{"given":"Hongsong","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Zhoushan Women and Children Hospital, Zhoushan, Zhejiang 316000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huasheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Zhoushan Women and Children Hospital, Zhoushan, Zhejiang 316000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyu","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Zhoushan Women and Children Hospital, Zhoushan, Zhejiang 316000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3435-5913","authenticated-orcid":true,"given":"Lieping","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Zhoushan Women and Children Hospital, Zhoushan, Zhejiang 316000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1590\/1414-431X20198595"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2859652"},{"issue":"6","key":"3","first-page":"1","article-title":"Deaths: preliminary data for 2011","volume":"61","author":"D. 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Hoyert","year":"2012","journal-title":"National Vital Statistics Reports: From the Centers for Disease Control and Prevention, National Center for Health Statistics, National Vital Statistics System"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1159\/000477419"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14458"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1097\/shk.0000000000000862"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.22694"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000007637"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0181704"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1177\/2150132720984426"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2017.278"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrtlng.2019.02.005"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1097\/shk.0000000000001332"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1186\/cc11353"},{"key":"15","first-page":"102","article-title":"The role of procalcitonin and blood lactic acid values in prognosis of sepsis and septic shock in polytrauma patients","volume":"279","author":"B. Kanashvili","year":"2018","journal-title":"Georgian Medical News"},{"issue":"3","key":"16","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/s00134-017-4683-6","article-title":"Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016","volume":"43","author":"A. Rhodes","year":"2017","journal-title":"Intensive Care Medicine"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1186\/cc7918"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2019.12.009"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.18433\/jpps29872"}],"updated-by":[{"DOI":"10.1155\/2023\/9856530","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T00:00:00Z","timestamp":1695772800000},"record-id":"55569"},{"DOI":"10.1155\/2023\/9856530","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T00:00:00Z","timestamp":1695772800000}}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2021\/5023733.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2021\/5023733.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2021\/5023733.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T22:50:10Z","timestamp":1636498210000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ecam\/2021\/5023733\/"}},"subtitle":[],"editor":[{"given":"Songwen","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,11,9]]},"references-count":19,"alternative-id":["5023733","5023733"],"URL":"https:\/\/doi.org\/10.1155\/2021\/5023733","relation":{"retraction":[{"id-type":"doi","id":"10.1155\/2023\/9856530","asserted-by":"object"}]},"ISSN":["1741-4288","1741-427X"],"issn-type":[{"value":"1741-4288","type":"electronic"},{"value":"1741-427X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11,9]]}}}