{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T15:09:00Z","timestamp":1764601740367,"version":"3.40.5"},"reference-count":57,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T00:00:00Z","timestamp":1639440000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Medicine International"],"published-print":{"date-parts":[[2021,12,14]]},"abstract":"<jats:p>Objective. To assess the clinical value and safety of the application of allogeneic equine oral mucosa mesenchymal stromal cells (OM-MSCs) to wounds. Animals. 8 healthy adult horses without front limb skin lesions or musculoskeletal disease. Procedures. Stem cells were isolated from the oral mucosa of a donor horse. Horses were subjected to the creation of eight full-thickness cutaneous wounds, two on each distal forelimb (FL) and two on both sides of the thorax (TH). Each wound was subjected to one out of four treatments: no medication (T1), hyaluronic acid- (HA-) gel containing OM-MSC (T2), HA-gel containing OM-MSC secretome (T3), and HA-gel alone (T4). Gross macroscopic evaluation and laser digital photographic documentation were regularly performed to allow wound assessment including wound surface area. Full-thickness skin punch biopsy was performed at each site before wound induction (D0, normal skin) and after complete wound healing (D62, repaired skin). Results. All wounds healed without adverse effect at D62. Distal limb wounds are slower to heal than body wounds. OM-MSC and its secretome have a positive impact on TH wound contraction. OM-MSC has a positive impact on the contraction and epithelialization of FL wounds. No significant difference between wound sites before and after treatment was noted at histological examination. Conclusion and Clinical Relevance. Using horse cells harvested from oral mucosa is a feasible technique to produce OM-MSC or its secretome. The gel produced by the combination of these biologic components with HA shows a positive impact when applied during the early stage of wound healing.<\/jats:p>","DOI":"10.1155\/2021\/5024905","type":"journal-article","created":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T20:50:09Z","timestamp":1639515009000},"page":"1-10","source":"Crossref","is-referenced-by-count":5,"title":["Effect of Allogeneic Oral Mucosa Mesenchymal Stromal Cells on Equine Wound Repair"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0845-0324","authenticated-orcid":true,"given":"Paola","family":"Di Francesco","sequence":"first","affiliation":[{"name":"Unit\u00e9 ICE-Groupe de Recherche en M\u00e9decine et R\u00e9\u00e9ducation des Equid\u00e9s de Sport (GREMERES), Centre for Equine Health, Ecole Nationale V\u00e9t\u00e9rinaire de Lyon, VetAgro Sup, Universit\u00e9 de Lyon, Marcy l\u2019Etoile 69280, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pauline","family":"Cajon","sequence":"additional","affiliation":[{"name":"Stem Cell Vet Therapeutics SAS, Elancourt 78990, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7679-2524","authenticated-orcid":true,"given":"Christophe","family":"Desterke","sequence":"additional","affiliation":[{"name":"INSERM UMR935, University of Medicine Paris Sud 11, Orsay, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8237-2198","authenticated-orcid":true,"given":"Marie-France","family":"Perron Lepage","sequence":"additional","affiliation":[{"name":"Vet Tox Path Consulting, Theiz\u00e9 69620, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4594-2398","authenticated-orcid":true,"given":"Jean-Jacques","family":"Lataillade","sequence":"additional","affiliation":[{"name":"Institut de Recherche Biom\u00e9dical des Arm\u00e9es, Unit\u00e9 de Th\u00e9rapie Cellulaire et R\u00e9paration Tissulaire, Br\u00e9tigny sur Orge 91223, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tewfik","family":"Kadri","sequence":"additional","affiliation":[{"name":"Stem Cell Vet Therapeutics SAS, Elancourt 78990, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0133-901X","authenticated-orcid":true,"given":"Olivier M.","family":"Lepage","sequence":"additional","affiliation":[{"name":"Unit\u00e9 ICE-Groupe de Recherche en M\u00e9decine et R\u00e9\u00e9ducation des Equid\u00e9s de Sport (GREMERES), Centre for Equine Health, Ecole Nationale V\u00e9t\u00e9rinaire de Lyon, VetAgro Sup, Universit\u00e9 de Lyon, Marcy l\u2019Etoile 69280, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"volume-title":"Equine Wound Management","year":"2008","author":"T. 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