{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:48:07Z","timestamp":1787017687016,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T00:00:00Z","timestamp":1640908800000},"content-version":"vor","delay-in-days":364,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32102733"],"award-info":[{"award-number":["32102733"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32060818"],"award-info":[{"award-number":["32060818"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (\n                    <jats:italic>S. aureus<\/jats:italic>\n                    ), a notorious pathogenic bacterium prevalent in the environment, causes a wide range of inflammatory diseases such as endometritis. Endometritis is an inflammatory disease in humans and mammals, which prolongs uterine involution and causes great economic losses. MiR\u201030a plays an importan trole in the process of inflammation; however, the regulatory role of miR\u201030a in endometritis is still unknown. Here, we first noticed that there was an increased level of miR\u201030a in uterine samples of cows with endometritis. And then, bovine endometrial epithelial (BEND) cells stimulated with the virulence factor lipoteichoic acid (LTA) from\n                    <jats:italic>S. aureus<\/jats:italic>\n                    were used as an in vitro endometritis model to explore the potential role of miR\u201030a in the pathogenesis of endometritis. Our data showed that the induction of the miR\u201030a expression is dependent on NF\u2010\n                    <jats:italic>\u03ba<\/jats:italic>\n                    B activation, and its overexpression significantly decreased the levels of IL\u20101\n                    <jats:italic>\u03b2<\/jats:italic>\n                    and IL\u20106. Furthermore, we observed that the overexpression of miR\u201030a inhibited its translation by binding to 3\u2009\n                    <jats:sup>\u2032<\/jats:sup>\n                    \u2212UTR of MyD88 mRNA, thus preventing the activation of Nox2 and NF\u2010\n                    <jats:italic>\u03ba<\/jats:italic>\n                    B and ROS accumulation. Meanwhile, in vivo studies further revealed that upregulation of miR\u201030a using chemically synthesized agomirs alleviates the inflammatory conditions in an experimental mouse model of endometritis, as indicated by inhibition of ROS and NF\u2010\n                    <jats:italic>\u03ba<\/jats:italic>\n                    B. Taken together, these findings highlight that miR\u201030a can attenuate LTA\u2010elicited oxidative stress and inflammatory responses through the MyD88\/Nox2\/ROS\/NF\u2010\n                    <jats:italic>\u03ba<\/jats:italic>\n                    B pathway and may aid the future development of novel therapies for inflammatory diseases caused by\n                    <jats:italic>S. aureus<\/jats:italic>\n                    , including endometritis.\n                  <\/jats:p>","DOI":"10.1155\/2021\/5042048","type":"journal-article","created":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T16:50:21Z","timestamp":1640969421000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Therapeutic Role of miR\u201030a in Lipoteichoic Acid\u2010Induced Endometritis via Targeting the MyD88\/Nox2\/ROS 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