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Patients with TNBC frequently develop resistance to chemotherapy. As epigenetic\u2010based antineoplastic drugs, histone deacetylase inhibitors (HDACis) have achieved particular efficacy in lymphoma but are less efficacious in solid tumors, and the resistance mechanism remains poorly understood. In this study, the GSE129944 microarray dataset from the Gene Expression Omnibus database was downloaded, and fold changes at the transcriptome level of a TNBC line (MDA\u2010MB\u2010231) after treatment with belinostat were identified. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were used to identify the critical biological processes. Construction and analysis of the protein\u2010protein interaction (PPI) network were performed to screen candidate genes related to cancer prognosis. A total of 465 DEGs were identified, including 240 downregulated and 225 upregulated genes. The cytokine\u2010cytokine receptor pathway was identified as being significantly changed. Furthermore, the expression of CXCL1 was implicated as a favorable factor in the overall survival of breast cancer patients. With\n                    <jats:italic>in vitro<\/jats:italic>\n                    approaches, we also showed that belinostat could induce the expression of CXCL1 in another 2 TNBC cell lines (BT\u2010549 and HCC\u20101937). We speculate that belinostat\u2010induced CXCL1 expression could be one of the results of the stress clone evolution of cells after HDACi treatment. These findings provide new insights into clone evolution during HDACi treatment, which might guide us to a novel perspective that various mutation\u2010targeted treatments should be implemented during the whole treatment cycle.\n                  <\/jats:p>","DOI":"10.1155\/2021\/5089371","type":"journal-article","created":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T16:13:42Z","timestamp":1618848822000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["CXCL1 Clone Evolution Induced by the HDAC Inhibitor Belinostat Might Be a Favorable Prognostic Indicator in Triple\u2010Negative Breast 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