{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T19:33:01Z","timestamp":1773171181483,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T00:00:00Z","timestamp":1636588800000},"content-version":"vor","delay-in-days":314,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2020M670002ZX"],"award-info":[{"award-number":["2020M670002ZX"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Intervertebral disc degeneration (IVDD) is the most significant cause of low back pain, the sixth\u2010largest disease burden globally, and the leading cause of disability. This study is aimed at investigating the molecular biological mechanism of Danggui\u2010Sini formula (DSF) mediated IVDD treatment. <jats:italic>Methods<\/jats:italic>. A potential gene set for DSF treatment of IVDD was identified through TCMSP, UniProt, and five disease gene databases. A protein interaction network of common targets between DSF and IVDD was established by using the STRING database. GO and KEGG enrichment analyses were performed using the R platform to discover the potential mechanism. Moreover, AutoDock Vina was used to verify molecular docking and calculate the binding energy. <jats:italic>Results<\/jats:italic>. A total of 119 active ingredients and 136 common genes were identified, including 10 core genes (AKT1, IL6, ALB, TNF, VEGFA, TP53, MAPK3, CASP3, JUN, and EGF). Enrichment analysis results showed that the therapeutic targets of DSF for diseases mainly focused on the AGE\u2010RAGE signaling pathway involved in diabetic complications, IL\u201017 signaling pathway, TNF signaling pathway, Toll\u2010like receptor signaling pathway, apoptosis, cellular senescence, PI3K\u2010Akt signaling pathway, and FoxO signaling pathway. These biological processes are induced mainly in response to oxidative stress and reactive oxygen species and the regulation of apoptotic signaling pathways. Molecular docking showed that there was a stable affinity between the core genes and the key components. <jats:italic>Conclusions<\/jats:italic>. The combination of network pharmacology and molecular docking provides a practical way to analyze the molecular biological mechanism of DSF\u2010mediated IVDD treatment, which confirms the \u201cmulticomponent, multitarget and multipathway\u201d characteristics of DSF and provides an essential theoretical basis for clinical practice.<\/jats:p>","DOI":"10.1155\/2021\/5165075","type":"journal-article","created":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T22:50:06Z","timestamp":1636671006000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Pharmacological Mechanism of Danggui\u2010Sini Formula for Intervertebral Disc Degeneration: A Network Pharmacology Study"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8179-0715","authenticated-orcid":false,"given":"Longjie","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9067-6423","authenticated-orcid":false,"given":"Jialiang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9512-5436","authenticated-orcid":false,"given":"Weishi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,11,11]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30970-9"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07360-1"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyw078"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000231761.73859.2c"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e31817e69d3"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.a171"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015504632021"},{"key":"e_1_2_11_8_2","article-title":"Effects of antiinflammatory drugs on the progression of osteoarthritis of the knee. 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