{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:41:53Z","timestamp":1747190513088,"version":"3.40.5"},"reference-count":16,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T00:00:00Z","timestamp":1632787200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Gastrointestinal Medicine"],"published-print":{"date-parts":[[2021,9,28]]},"abstract":"<jats:p>Inflammatory bowel disease (IBD) and psoriasis are chronic inflammatory immune-mediated diseases. The interleukin-23- (IL23-) T helper (Th)17 pathway has been implicated in their pathogenesis, with multiple biologic therapies targeting this pathway. IL-17, the main proinflammatory cytokine produced by (TH)17, has been targeted by antibodies and IL-17 receptor blockers with favorable outcomes in treating psoriasis and psoriatic arthritis. However, their role in IBD is unpredictable as studies reported worsening of IBD with agents targeting IL-17 and rare case reports with new-onset IBD. We present a case of Crohn's-like severe terminal ileitis and worsening diverticulitis complicated by intestinal perforation requiring total parenteral nutrition shortly after being started on secukinumab.<\/jats:p>","DOI":"10.1155\/2021\/5213876","type":"journal-article","created":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T16:07:04Z","timestamp":1632845224000},"page":"1-4","source":"Crossref","is-referenced-by-count":0,"title":["Novel Presentation of Terminal Ileitis Associated with Secukinumab Therapy"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2980-8102","authenticated-orcid":true,"given":"Aciel","family":"Ahmed Shaheen","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, William Beaumont Hospital at Royal Oak, 3535 W. 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