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Methods. A total of 30 male prostate cancer patients who received ADT were selected. All candidates were scored using the Ocular Surface Disease Index (OSDI) and subsequently divided into two groups containing 9 symptomatic patients (scores &gt;12) and 21 asymptomatic patients (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mtext>scores<\/a:mtext>\n                        <a:mo>\u2264<\/a:mo>\n                        <a:mn>12<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). Another 20 healthy age-matched males were selected as the control group. Each candidate was assessed with respect to eyelid margin abnormality, tear film break-up time (NI-BUT), tear meniscus height (TMH), meiboscore, meibum expressibility, and demodex infection. Results. The NI-BUT in the ADT group was significantly shorter than that in the control group. The scores for OSDI, eyelid margin abnormality, meibum expressibility, and meiboscores were significantly higher in the ADT group (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). Moreover, the NI-BUT in the symptomatic ADT group was significantly shorter than that in the asymptomatic ADT group (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.05<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>). The meiboscores and meibum expressibility score in the symptomatic ADT group were significantly higher than those in the asymptomatic ADT group (<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>&lt;<\/g:mo>\n                        <g:mn>0.05<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>). The presence of demodex in the symptomatic ADT group was also higher than that in the asymptomatic ADT group (<jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>P<\/i:mi>\n                        <i:mo>&lt;<\/i:mo>\n                        <i:mn>0.05<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>).The length of time that patients had been taking ADT was positively correlated with meiboscores and negatively correlated with NI-BUT. Conclusion. Androgen levels were associated with significant changes in relative meibomian gland function. Subjective symptoms, such as dryness and foreign body sensation, were more obvious in prostate cancer patients receiving ADT, which may be caused by MGD and demodex infection. It\u2019s recommended that more attention be paid to the ocular surface in prostate cancer patients taking ADT by performing examination of NI-BUT and meibomian gland morphology and function with a view to providing more comprehensive prevention and treatment protocols.<\/jats:p>","DOI":"10.1155\/2021\/5390195","type":"journal-article","created":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T21:35:09Z","timestamp":1636493709000},"page":"1-6","source":"Crossref","is-referenced-by-count":7,"title":["The Ocular Surface Characteristics in Prostate Cancer Patients Treated with Androgen Deprivation Therapy"],"prefix":"10.1155","volume":"2021","author":[{"given":"Weina","family":"Li","sequence":"first","affiliation":[{"name":"Eye Institute & Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen, China"},{"name":"Fujian Provincial Key Laboratory of Ophthalmology and Visual Science & Ocular Surface and Corneal Diseases, Xiamen, China"},{"name":"Department of Ophthalmology, Changhai Hospital, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Li","sequence":"additional","affiliation":[{"name":"Eye Institute & Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feilun","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Urology, Zhenjiang First People\u2019s Hospital, Zhenjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhipeng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Urology, Zhenjiang First People\u2019s Hospital, Zhenjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9538-6158","authenticated-orcid":true,"given":"Nuo","family":"Dong","sequence":"additional","affiliation":[{"name":"Eye Institute & Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen, China"},{"name":"Fujian Provincial Key Laboratory of Ophthalmology and Visual Science & Ocular Surface and Corneal Diseases, Xiamen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0449-3709","authenticated-orcid":true,"given":"Cheng","family":"Li","sequence":"additional","affiliation":[{"name":"Eye Institute & Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen, China"},{"name":"Fujian Provincial Key Laboratory of Ophthalmology and Visual Science & Ocular Surface and Corneal Diseases, Xiamen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.22.4.232"},{"issue":"3","key":"2","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/bju.14168","article-title":"Are all gonadotrophin-releasing hormone agonists equivalent for the treatment of prostate cancer? 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