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However, malware attacks have also widely proliferated, mainly aiming at legitimate network users, resulting in millions of dollars in damages if proper protection and response measures are not settled and enforced. In this context, the paper at hand proposes MalSEIRS, a novel dynamic model, to predict malware distribution in a network based on the SEIRS epidemiological model. As a result, the time\u2010dependent rates of infection, recovery, and loss of immunity enable us to capture the complex dynamism of malware spreading behavior, which is influenced by a variety of external circumstances. In addition, we describe both offensive and defensive techniques, based on the proposed MalSEIRS model, through extensive experimentation, as well as disclosing real\u2010life malware campaigns that can be better understood by using the suggested model.<\/jats:p>","DOI":"10.1155\/2021\/5415724","type":"journal-article","created":{"date-parts":[[2021,12,27]],"date-time":"2021-12-27T22:35:19Z","timestamp":1640644519000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["MalSEIRS: Forecasting Malware Spread Based on Compartmental Models in Epidemiology"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0028-4595","authenticated-orcid":false,"given":"Isabella","family":"Mart\u00ednez Mart\u00ednez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7212-522X","authenticated-orcid":false,"given":"Andr\u00e9s","family":"Flori\u00e1n Quiti\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7244-2631","authenticated-orcid":false,"given":"Daniel","family":"D\u00edaz-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4041-1205","authenticated-orcid":false,"given":"Pantaleone","family":"Nespoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6424-3322","authenticated-orcid":false,"given":"F\u00e9lix","family":"G\u00f3mez M\u00e1rmol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,27]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.3390\/s19071492"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/sym10120669"},{"key":"e_1_2_11_3_2","first-page":"1","article-title":"Using reverse engineering to face malware","volume":"15","author":"S\u00e1nchez C.","year":"2019","journal-title":"Revista Ingenieria Solidaria"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.procs.2019.09.173"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.26636\/jtit.2019.130218"},{"key":"e_1_2_11_6_2","volume-title":"Cybersecurity Legislation and Ransomware Attacks in the united states, 2015-2019","author":"Joseph S."},{"key":"e_1_2_11_7_2","volume-title":"The Sir Model and the Foundations of Public Health","author":"Weiss H. 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