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Recently, abnormal H<jats:sub>2<\/jats:sub>S concentration has been associated with several pathophysiological states, such as diabetes mellitus, hypertension, Alzheimer\u2019s disease, and Parkinson\u2019s disease. As regulating H<jats:sub>2<\/jats:sub>S concentration can be a very prominent way of developing new drugs, many researchers have paid great attention to H<jats:sub>2<\/jats:sub>S research. To understand the role of H<jats:sub>2<\/jats:sub>S in pathophysiology and develop H<jats:sub>2<\/jats:sub>S\u2010based therapies, it is necessary to measure the exact concentration of H<jats:sub>2<\/jats:sub>S within biological systems. But, H<jats:sub>2<\/jats:sub>S is volatile and can be easily oxidized. Besides, the active sites for several biological effects of H<jats:sub>2<\/jats:sub>S are inside the cell. Therefore, there is a need for the development of new methods for the accurate and reliable detection of H<jats:sub>2<\/jats:sub>S within live cells. 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