{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T19:44:46Z","timestamp":1774035886904,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T00:00:00Z","timestamp":1626220800000},"content-version":"vor","delay-in-days":194,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Pediatrics"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n                    The normal development of puberty depends on the specific pulsatility of gonadorelin, which is finely regulated by genetic and environmental factors. In the published literature, eating disorders figure as a cause of pubertal delay\/arrest in females but are rarely considered in males with disordered puberty. A 16.7\u2010year\u2010old male was referred to the Department of Pediatrics with arrested puberty due to severe malnutrition in the context of food restriction. Past medical history was relevant for asthma. Generalized cachexia, facial lanugo hair, cutaneous xerosis, and Russell\u2019s sign were noted; he had a height of 155.5\u2009cm (\u22122.5 SD; target height: 168\u2009cm, \u22121.1 SD) and a BMI of 12.4\u2009kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    (\u22126.8 SD); left and right testicular volumes were 8\u2009mL and 10\u2009mL, respectively. He had a twin brother who had normal auxological\/pubertal development (height: 167\u2009cm, \u22121.05 SD; testicular volumes: 20\u2009mL). Anorexia nervosa was diagnosed, and he was enrolled in a personalized treatment and surveillance program. \u201cNonthyroid illness\u201d resembling secondary hypothyroidism was noted, as was low bone mineral density. Clinical and biochemical follow\u2010up showed significant improvements in BMI (16.2\u2009kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    , \u22122.55 SD), completion of puberty (testicular volumes: 25\u2009mL), and reversion of main neuroendocrine abnormalities. Herein, we present an adolescent male with arrested puberty in the context of anorexia nervosa. The recognition of this rare condition in males allows a personalized approach to disordered puberty, with resumption of normal function of the hypothalamic\u2010pituitary\u2010gonadal axis and achievement of pubertal milestones.\n                  <\/jats:p>","DOI":"10.1155\/2021\/5512532","type":"journal-article","created":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T15:05:07Z","timestamp":1626275107000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Arrested Puberty in an Adolescent Male with Anorexia Nervosa Successfully Resumed with Multidisciplinary Care"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3529-7871","authenticated-orcid":false,"given":"Diana","family":"Sim\u00e3o 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