{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:03:11Z","timestamp":1778976191421,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T00:00:00Z","timestamp":1618358400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002660","name":"Islamic Azad University","doi-asserted-by":"publisher","award":["1399.514"],"award-info":[{"award-number":["1399.514"]}],"id":[{"id":"10.13039\/501100002660","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Stroke Research and Treatment"],"published-print":{"date-parts":[[2021,4,14]]},"abstract":"<jats:p>Background. The purpose of present study was to assess the impact of maternal treadmill exercise during pregnancy on inflammation, oxidative stress, expression of Bax and Bcl-2 genes, and brain-derived neurotrophic factor (BDNF) level in neonatal rat brain after the hypoxia-ischemia injury. Material and Methods. A total of 24 female Wistar rats were utilized in this research. Two groups are randomly considered for rats: (1) not exercised through pregnancy and (2) exercised during pregnancy. Offsprings were divided into four groups including after delivery: (1) sham, (2) sham\/exercise (sham\/EX), (3) HI, and (4) HI+exercise. HI was induced in pups at postnatal day 8. Neurobehavioral tests were done seven days after HI induction. Then, the brain tissue was taken from the skull to estimate Bcl-2 and Bax gene expressions, BDNF, cerebral edema, infarct volume, inflammatory factors, oxidative stress, and neurological function. Results. The BDNF level in the HI+exercise group was considerably higher than the HI, sham, and sham\/EX groups. Tumor necrosis factor (TNF-\u03b1), C-reactive protein (CRP), and the whole oxidant capacity (TOC) levels in the HI group were significantly higher than the sham and sham\/EX groups. TNF-\u03b1, CRP, and TOC levels in the HI+exercise group were significantly lower than the HI group. Total antioxidant capacity (TAC) level in the HI+exercise group was significantly higher than the HI group. Infarct volume and edema percent in the HI+exercise group were significantly lower than the HI group. Neurological function in the HI+exercise group was significantly better than the HI group. Bax expression in the HI+exercise group was significantly lower than the HI group. Bcl-2 expression in the HI+exercise group was significantly higher than the HI group. In the sham group, BDNF, TNF-\u03b1, CRP, TAC, TOC, edema levels, and neurological function had no significant difference with the sham\/EX group. Conclusion. It appears that the maternal treadmill exercise during pregnancy exerts a supportive impact against neonatal HI brain injury through increasing antioxidant capacity, Bcl-2 expression, and BDNF levels and decreasing inflammation that is resulted in the lower infarct volume and sensorimotor dysfunction.<\/jats:p>","DOI":"10.1155\/2021\/5512745","type":"journal-article","created":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T23:22:20Z","timestamp":1618442540000},"page":"1-10","source":"Crossref","is-referenced-by-count":4,"title":["Treadmill Exercise during Pregnancy Decreased Vulnerability to Neonatal Hypoxia-Ischemia through Reducing Inflammation and Increasing Antiapoptotic Gene Expressions and Antioxidant Capacity in Rats"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6154-443X","authenticated-orcid":true,"given":"Elahe","family":"Gorgij","sequence":"first","affiliation":[{"name":"Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1345-2052","authenticated-orcid":true,"given":"Hamed","family":"Fanaei","sequence":"additional","affiliation":[{"name":"Pregnancy Health Research Center, Zahedan University of Medical Sciences, Zahedan, Iran"},{"name":"Department of Physiology, Zahedan University of Medical Sciences, Zahedan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3071-666X","authenticated-orcid":true,"given":"Parichehr","family":"Yaghmaei","sequence":"additional","affiliation":[{"name":"Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6880-297X","authenticated-orcid":true,"given":"Mohammad Reza","family":"Shahraki","sequence":"additional","affiliation":[{"name":"Department of Physiology, Zahedan University of Medical Sciences, Zahedan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6423-2578","authenticated-orcid":true,"given":"Hadi","family":"Mirahmadi","sequence":"additional","affiliation":[{"name":"Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences, Zahedan, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2017.110"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2013.150"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202001571"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2010.33"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1177\/1933719111401656"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(94)00357-2"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-10-61"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.obmed.2019.100111"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1002\/jdn.10008"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.11.051"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410090206"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1038\/srep09504"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200210000-00018"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.4172\/2165-7904.1000343"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1123\/jpah.2013-0390"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1177\/0890334418759261"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/2358391"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6398520"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.endonu.2012.05.012"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080225"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1177\/1933719114556485"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1002\/jdn.10055"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1159\/000512698"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1017\/s2040174417000617"},{"issue":"9","key":"25","first-page":"955","article-title":"Maternal voluntary exercise during pregnancy enhances the spatial learning acquisition but not the retention of memory in rat pups via a TrkB-mediated mechanism: the role of hippocampal BDNF expression","volume":"16","author":"M. 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