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This disease is not a serious disease commonly, but it is one of the most widespread infectious diseases which can still be fatal. HFMD still poses a threat to the lives and health of children and adolescents. An effective prediction model would be very helpful to HFMD control and prevention. Several methods have been proposed to predict HFMD outpatient cases. These methods tend to utilize the connection between cases and exogenous data, but exogenous data is not always available. In this paper, a novel method combined time series composition and local fusion has been proposed. The Empirical Mode Decomposition (EMD) method is used to decompose HFMD outpatient time series. Linear local predictors are applied to processing input data. The predicted value is generated via fusing the output of local predictors. The evaluation of the proposed model is carried on a real dataset comparing with the state\u2010of\u2010the\u2010art methods. The results show that our model is more accurately compared with other baseline models. Thus, the model we proposed can be an effective method in the HFMD outpatient prediction mission.<\/jats:p>","DOI":"10.1155\/2021\/5514743","type":"journal-article","created":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T22:35:27Z","timestamp":1620945327000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prediction of HFMD Cases by Leveraging Time Series Decomposition and Local Fusion"],"prefix":"10.1155","volume":"2021","author":[{"given":"Ziyang","family":"Wang","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7962-2827","authenticated-orcid":false,"given":"Zhijin","family":"Wang","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5933-2355","authenticated-orcid":false,"given":"Yingxian","family":"Lin","sequence":"additional","affiliation":[]},{"given":"Jinming","family":"Liu","sequence":"additional","affiliation":[]},{"given":"Yonggang","family":"Fu","sequence":"additional","affiliation":[]},{"given":"Peisong","family":"Zhang","sequence":"additional","affiliation":[]},{"given":"Bing","family":"Cai","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2021,5,13]]},"reference":[{"key":"e_1_2_10_1_2","unstructured":"C C for Disease Control Prevention The general situation of notifiable infectious diseases in china in 2019 2020 2020 http:\/\/www.nhc.gov.cn\/jkj\/s3578\/202004\/b1519e1bc1a944fc8ec176db600f68d1.shtml."},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1017\/s0950268815001144"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-016263"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-54495-2"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-68840-3"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1137\/0515056"},{"key":"e_1_2_10_7_2","doi-asserted-by":"crossref","unstructured":"WenQ. 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