{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T04:23:25Z","timestamp":1785471805933,"version":"3.56.0"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T00:00:00Z","timestamp":1617321600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019349","name":"Nanjing Medical Science and Technique Development Foundation","doi-asserted-by":"crossref","award":["QRX17033"],"award-info":[{"award-number":["QRX17033"]}],"id":[{"id":"10.13039\/501100019349","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100019349","name":"Nanjing Medical Science and Technique Development Foundation","doi-asserted-by":"crossref","award":["BK20161116"],"award-info":[{"award-number":["BK20161116"]}],"id":[{"id":"10.13039\/501100019349","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004608","name":"Jiangsu Provincial Natural Science Foundation","doi-asserted-by":"crossref","award":["QRX17033"],"award-info":[{"award-number":["QRX17033"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004608","name":"Jiangsu Provincial Natural Science Foundation","doi-asserted-by":"crossref","award":["BK20161116"],"award-info":[{"award-number":["BK20161116"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neural Plasticity"],"published-print":{"date-parts":[[2021,4,2]]},"abstract":"<jats:p>Objective. To treat children with acute nonsuppurative otitis media induced by acute upper respiratory tract infection of varying severity and evaluate its therapeutic effects. Materials and Methods. Patients from the emergency department with acute nonsuppurative otitis media were followed up between September 2015 and December 2018. A total of 420 patients were classified into grades I to III according to tympanic membrane intactness and systemic reactions and treated according to grading. Results. Grade I patients showed no significant difference in the recovery of acute symptoms whether antibiotics are used or not. Grade II patients, after 3 months of follow-up, showed no tympanic membrane perforation, and 9 cases of binaural B-type children did not improve but were cured by operation. In grade III patients, after treatment for 4 hours in the experimental group 3, the earache subsided, 1 case had tympanic membrane perforation, and the patients recovered after 2 weeks (64\/92) and after 3 months (28\/92) of drug treatment. After treatment for 4\u2009h in the control group 3, the earache eased, and 3 patients developed tympanic membrane perforation and were treated for 3 months. 4 binaural B-type children did not improve but recovered after surgical treatment. Conclusion. Grade I patients could be closely followed up by clinical observation. For anti-inflammatory patients with grade II disease, treatment has therapeutic significance. For patients with grade III, some patients still have TMP, but the use of cephalosporin third-generation drugs plus an appropriate amount of hormone therapy is effective in reducing symptoms and tympanic local reactions.<\/jats:p>","DOI":"10.1155\/2021\/5517209","type":"journal-article","created":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T19:20:50Z","timestamp":1617650450000},"page":"1-8","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of Clinical Graded Treatment of Acute Nonsuppurative Otitis Media in Children with Acute Upper Respiratory Tract Infection"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6563-7959","authenticated-orcid":true,"given":"Wei","family":"Meng","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, Nanjing Tongren Hospital, School of Medicine, Southeast University Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5544-685X","authenticated-orcid":true,"given":"Dong-Dong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, Nanjing Tongren Hospital, School of Medicine, Southeast University Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0515-5218","authenticated-orcid":true,"given":"Guang-Fei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, Nanjing Tongren Hospital, School of Medicine, Southeast University Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1431-8998","authenticated-orcid":true,"given":"Zi-Hui","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, Nanjing Tongren Hospital, School of Medicine, Southeast University Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5171-8819","authenticated-orcid":true,"given":"Shuang-Ba","family":"He","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery, Nanjing Tongren Hospital, School of Medicine, Southeast University Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2009.09.006"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1086\/509332"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.1040771"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02011-12"},{"issue":"4","key":"5","first-page":"390","article-title":"The comparison of single-dose ceftriaxone, five-day azithromycin, and ten-day amoxicillin\/clavulanate for the treatment of children with acute otitis media","volume":"49","author":"B. 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