{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T01:24:13Z","timestamp":1773797053033,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T00:00:00Z","timestamp":1628035200000},"content-version":"vor","delay-in-days":215,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Dibutyl phthalate is an endocrine disruptor used in a wide range of industrial and agriculture applications. The present study focuses on elucidating the effect of subacute exposure (4\u2010weeks) of DBP on insulin and its sensitivity indexes, oxidative status, thyroid function, energy metabolites, serum biochemistry, and anthropometry in rats. A total of 64 rats were divided into 4 treatment groups as mg DBP\/Kg body weight per day: (a) 0\u2009mg\/Kg (control), (b) 10\u2009mg\/Kg (DBP\u201010), (c) 50\u2009mg\/Kg (DBP\u201050), and (d) 100\u2009mg\/Kg (DBP\u2010100). The rats in each treatment (<jats:italic>n<\/jats:italic> = 16) were further divided into male (<jats:italic>n<\/jats:italic> = 8) and female (<jats:italic>n<\/jats:italic> = 8) rats for studying treatment and gender interactions. Intraperitoneal glucose tolerance test (IPGTT) was performed on the 21<jats:sup>st<\/jats:sup> day. Anthropometry, nutritional determinants, fasting plasma glucose, fasting plasma insulin, homeostatic model assessment (HOMA), thyroid hormones, energy metabolites, and oxidative status were studied during the experimental period. Two\u2010way ANOVA was used to analyze the data (<jats:italic>p<\/jats:italic> &lt; 0.05). Tukey\u2019s posthoc test was used for pair\u2010wise comparisons. DBP increased body weight gain and feed efficiency in an inverted nonmonotonic <jats:italic>U<\/jats:italic>\u2010shaped fashion. Hyperglycemia and increased blood glucose area under the curve were observed in DBP\u2010100 at 120 minutes in IPGTT. The HOMA also showed a linear monotonic contrast. Thyroxin decreased significantly in the DBP\u2010100 rats, whereas malondialdehyde, nonesterified fatty acids, and beta hydroxyl butyrate were increased with the DBP treatments. In conclusion, DBP could be attributed to the development of hyperglycemia and insulin resistance in rats. Further investigations into the lipid peroxidation pathways can improve our understanding of the mechanisms involved in metabolic disruption.<\/jats:p>","DOI":"10.1155\/2021\/5521516","type":"journal-article","created":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T00:35:07Z","timestamp":1628123707000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effects of Subacute Exposure of Dibutyl Phthalate on the Homeostatic Model Assessment, Thyroid Function, and Redox Status in Rats"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4929-4033","authenticated-orcid":false,"given":"Khalid Abdul","family":"Majeed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1106-6289","authenticated-orcid":false,"given":"Muhammad 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