{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T00:25:53Z","timestamp":1771028753879,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,3,20]],"date-time":"2021-03-20T00:00:00Z","timestamp":1616198400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Psychiatry"],"published-print":{"date-parts":[[2021,3,20]]},"abstract":"<jats:p>Homocystinuria is a rare autosomal recessive metabolic disorder due to a defect in the cystathionine \u03b2-synthase (CBS) that leads to high homocysteine plasma levels. Psychiatric symptoms secondary to homocystinuria have been described in the literature; however, there is a lack of information about obsessive-compulsive symptoms correlated to this disorder. We describe the case of a 39 years old man, diagnosed with homocystinuria in childhood, with no previous psychiatric history that presented obsessive-compulsive disorder (OCD) like symptoms, as a manifestation of homocystinuria. This case underlines the importance for a psychiatrist to explore medical nonpsychiatric history, especially when presentation is abrupt, atypical, or in treatment-resistant cases.<\/jats:p>","DOI":"10.1155\/2021\/5523453","type":"journal-article","created":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T22:35:05Z","timestamp":1616452505000},"page":"1-3","source":"Crossref","is-referenced-by-count":2,"title":["Obsessive-Compulsive Symptoms as a Manifestation of Homocystinuria"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2537-3287","authenticated-orcid":true,"given":"Vera","family":"Froes","sequence":"first","affiliation":[{"name":"Centro Hospitalar Barreiro Montijo, Barreiro, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4237-8146","authenticated-orcid":true,"given":"Hugo","family":"Afonso","sequence":"additional","affiliation":[{"name":"Centro Hospitalar Tondela Viseu, Viseu, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4353-8690","authenticated-orcid":true,"given":"Zita","family":"Gameiro","sequence":"additional","affiliation":[{"name":"Centro Hospitalar Barreiro Montijo, Barreiro, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","volume-title":"Homocystinuria caused by cystathionine beta-synthase deficiency","author":"S. 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