{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:47:26Z","timestamp":1791946046934,"version":"4.3.4"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T00:00:00Z","timestamp":1619049600000},"content-version":"vor","delay-in-days":111,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Dermatology Research and Practice"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Vitiligo is a chronic condition characterized by skin depigmentation. Although not life\u2010threatening, it significantly impacts quality of life. The pathophysiology of vitiligo remains poorly understood, and treatment options are limited. Mounting evidence supports the importance of autoreactive T cells and, particularly interleukin\u201017A\u2010 (IL\u201017A\u2010) secreting Th17\u2009cells, in vitiligo. IL\u201017A targeting has been proven successful in various inflammatory dermatological conditions, including psoriasis and lupus erythematosus. <jats:italic>Objective<\/jats:italic>. We evaluated the relationship between serum levels of IL\u201017A and the clinicopathological characteristics of Vietnamese vitiligo patients. <jats:italic>Methods<\/jats:italic>. In this cross\u2010sectional study, we analyzed data from 52 nonsegmental vitiligo patients and 50 age\u2010 and sex\u2010matched healthy individuals. Serum levels of IL\u201017A were measured using an enzyme\u2010linked immunosorbent assay. We evaluated the correlation between IL\u201017A levels and clinical characteristics including leukotrichia, disease duration, vitiligo activity, and body surface area involvement. <jats:italic>Results<\/jats:italic>. Patients with progressive vitiligo had significantly higher IL\u201017A levels than patients with stable vitiligo (<jats:italic>P<\/jats:italic>\u2009=\u20090.014) or healthy individuals (<jats:italic>P<\/jats:italic>\u2009=\u20090.002). In addition, serum IL\u201017A levels were higher in vitiligo patients with leukotrichia than in patients without it (<jats:italic>P<\/jats:italic>\u2009=\u20090.04). Furthermore, serum IL\u201017A levels were negatively correlated with age (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.39, <jats:italic>P<\/jats:italic>\u2009=\u20090.004) and age of onset (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.33, <jats:italic>P<\/jats:italic>\u2009=\u20090.016) in vitiligo patients. <jats:italic>Conclusions<\/jats:italic>. Higher serum levels of IL\u201017A in patients with progressive vitiligo and leukotrichia suggest a potential role of IL\u201017A in melanocyte destruction in the epidermis and the follicular matrix.<\/jats:p>","DOI":"10.1155\/2021\/5524566","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T09:39:29Z","timestamp":1619084369000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Increased Circulatory Interleukin\u201017A Levels in Patients with Progressive and Leukotrichial Vitiligo"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3222-758X","authenticated-orcid":false,"given":"Thai Van Thanh","family":"Le","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8286-4712","authenticated-orcid":false,"given":"Huy","family":"Ngoc Phan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5287-0265","authenticated-orcid":false,"given":"Tran Ngoc","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5382-9283","authenticated-orcid":false,"given":"Le Duy","family":"Pham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,22]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.11.061"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2003.00032.x"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2011.05377.x"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2004.00130.x"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2000.130106.x"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2005.00244.x"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2003.00023.x"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0190-9622(86)70085-6"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2010.00563.x"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.07.011"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.3978\/j.issn.2305-5839.2015.11.36"},{"key":"e_1_2_8_12_2","first-page":"508","article-title":"Aggressive skin cancers occurring in patients treated with the janus kinase inhibitor ruxolitinib","volume":"16","author":"Blechman A. 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