{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T13:33:33Z","timestamp":1751463213181,"version":"3.37.3"},"reference-count":64,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T00:00:00Z","timestamp":1618444800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funding Scheme for Training Young Teachers in Shanghai Colleges","award":["ZZJKYX19009","PWZzk2017-31","18DZ2260400","81830052","81772829"],"award-info":[{"award-number":["ZZJKYX19009","PWZzk2017-31","18DZ2260400","81830052","81772829"]}]},{"name":"Discipline Construction Program of the Pudong New District Health Bureau of Shanghai","award":["ZZJKYX19009","PWZzk2017-31","18DZ2260400","81830052","81772829"],"award-info":[{"award-number":["ZZJKYX19009","PWZzk2017-31","18DZ2260400","81830052","81772829"]}]},{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"publisher","award":["ZZJKYX19009","PWZzk2017-31","18DZ2260400","81830052","81772829"],"award-info":[{"award-number":["ZZJKYX19009","PWZzk2017-31","18DZ2260400","81830052","81772829"]}],"id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015377","name":"Shanghai Key Laboratory of Molecular Imaging","doi-asserted-by":"publisher","award":["ZZJKYX19009","PWZzk2017-31","18DZ2260400","81830052","81772829"],"award-info":[{"award-number":["ZZJKYX19009","PWZzk2017-31","18DZ2260400","81830052","81772829"]}],"id":[{"id":"10.13039\/501100015377","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015378","name":"Shanghai University of Medicine and Health Sciences","doi-asserted-by":"publisher","award":["ZZJKYX19009","PWZzk2017-31","18DZ2260400","81830052","81772829"],"award-info":[{"award-number":["ZZJKYX19009","PWZzk2017-31","18DZ2260400","81830052","81772829"]}],"id":[{"id":"10.13039\/501100015378","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["ZZJKYX19009","PWZzk2017-31","18DZ2260400","81830052","81772829"],"award-info":[{"award-number":["ZZJKYX19009","PWZzk2017-31","18DZ2260400","81830052","81772829"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2021,4,15]]},"abstract":"<jats:p>Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease that primarily affects motor neurons, causing muscle atrophy, bulbar palsy, and pyramidal tract signs. However, the aetiology and pathogenesis of ALS have not been elucidated to date. In this study, a competitive endogenous RNA (ceRNA) network was constructed by analyzing the expression profiles of messenger RNAs (mRNAs) and long noncoding RNAs (lncRNAs) that were matched by 7 ALS samples and 4 control samples, and then a protein-protein interaction (PPI) network was constructed to identify the genes related to ALS. Gene Ontology (GO) was used to study the potential functions of differentially expressed mRNAs (DEmRNAs) in the ceRNA network. For the ALS and control groups, 247177 potential lncRNA-mRNA ceRNA relationship pairs were screened. Analysis of significant relationship pairs demonstrated that the PPI modules formed by the MALAT1-regulated SYNRG, ITSN2, PICALM, AP3B1, and AAK1 genes may play important roles in the pathogenesis of ALS, and these results may help to characterize the pathogenesis of ALS.<\/jats:p>","DOI":"10.1155\/2021\/5526179","type":"journal-article","created":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T22:21:44Z","timestamp":1618611704000},"page":"1-12","source":"Crossref","is-referenced-by-count":6,"title":["The Novel Regulatory Role of lncRNA-miRNA-mRNA Axis in Amyotrophic Lateral Sclerosis: An Integrated Bioinformatics Analysis"],"prefix":"10.1155","volume":"2021","author":[{"given":"Dingsheng","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Oncology and Hematology, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1838-9312","authenticated-orcid":true,"given":"Xiaojia","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, China"}]},{"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, China"}]},{"given":"Rui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, China"}]},{"given":"Donglin","family":"Lai","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, China"}]},{"given":"Kaijie","family":"Chen","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, China"}]},{"given":"Yuru","family":"Han","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, China"}]},{"given":"Guoqing","family":"Wan","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1943-5106","authenticated-orcid":true,"given":"Yanjun","family":"Zheng","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0812-9162","authenticated-orcid":true,"given":"Changlian","family":"Lu","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8718-2067","authenticated-orcid":true,"given":"Xuefeng","family":"Gu","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, China"},{"name":"Research Department, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, China"}]}],"member":"311","reference":[{"doi-asserted-by":"publisher","key":"1","DOI":"10.1016\/j.brainres.2018.12.016"},{"key":"2","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1136\/jmedgenet-2020-106866","article-title":"Evidence for polygenic and oligogenic basis of Australian sporadic amyotrophic lateral sclerosis","volume":"58","author":"E. P. McCann","year":"2021","journal-title":"Journal of Medical Genetics"},{"doi-asserted-by":"publisher","key":"3","DOI":"10.1155\/2020\/6101838"},{"doi-asserted-by":"publisher","key":"4","DOI":"10.1126\/science.aav2606"},{"doi-asserted-by":"publisher","key":"5","DOI":"10.1007\/978-3-319-53889-1_14"},{"doi-asserted-by":"publisher","key":"6","DOI":"10.1038\/nature08971"},{"doi-asserted-by":"publisher","key":"7","DOI":"10.1016\/S1474-4422(18)30394-6"},{"doi-asserted-by":"publisher","key":"8","DOI":"10.1038\/s41586-020-2288-7"},{"doi-asserted-by":"publisher","key":"9","DOI":"10.1073\/pnas.1913956117"},{"doi-asserted-by":"publisher","key":"10","DOI":"10.1006\/nbdi.1997.0163"},{"doi-asserted-by":"publisher","key":"11","DOI":"10.1038\/nature10353"},{"doi-asserted-by":"publisher","key":"12","DOI":"10.1038\/nrg2680"},{"doi-asserted-by":"publisher","key":"13","DOI":"10.1111\/ggi.12022"},{"doi-asserted-by":"publisher","key":"14","DOI":"10.1038\/nature11280"},{"doi-asserted-by":"publisher","key":"15","DOI":"10.1007\/s00415-020-09861-w"},{"doi-asserted-by":"publisher","key":"16","DOI":"10.3389\/fnmol.2020.00078"},{"doi-asserted-by":"publisher","key":"17","DOI":"10.3389\/fnins.2017.00731"},{"doi-asserted-by":"publisher","key":"18","DOI":"10.3389\/fnmol.2016.00069"},{"doi-asserted-by":"publisher","key":"19","DOI":"10.1007\/s12031-018-1204-1"},{"doi-asserted-by":"publisher","key":"20","DOI":"10.1007\/s00018-018-2873-1"},{"doi-asserted-by":"publisher","key":"21","DOI":"10.1038\/s41598-018-20679-5"},{"doi-asserted-by":"publisher","key":"22","DOI":"10.1016\/j.neulet.2019.03.048"},{"doi-asserted-by":"publisher","key":"23","DOI":"10.1016\/j.gene.2012.07.058"},{"doi-asserted-by":"publisher","key":"24","DOI":"10.1016\/j.cell.2011.07.014"},{"doi-asserted-by":"publisher","key":"25","DOI":"10.1093\/bib\/bbw084"},{"doi-asserted-by":"publisher","key":"26","DOI":"10.1002\/humu.24055"},{"doi-asserted-by":"publisher","key":"27","DOI":"10.1038\/srep29395"},{"doi-asserted-by":"publisher","key":"28","DOI":"10.1371\/journal.pbio.2007044"},{"doi-asserted-by":"publisher","key":"29","DOI":"10.1038\/s41467-019-11637-4"},{"doi-asserted-by":"publisher","key":"30","DOI":"10.1093\/hmg\/ddg184"},{"doi-asserted-by":"publisher","key":"31","DOI":"10.1152\/physiolgenomics.00017.2007"},{"doi-asserted-by":"publisher","key":"32","DOI":"10.1016\/j.brainresbull.2019.01.019"},{"doi-asserted-by":"publisher","key":"33","DOI":"10.1038\/nn.2778"},{"doi-asserted-by":"publisher","key":"34","DOI":"10.1016\/j.cell.2009.03.006"},{"doi-asserted-by":"publisher","key":"35","DOI":"10.1038\/nature09320"},{"doi-asserted-by":"publisher","key":"36","DOI":"10.1038\/ng.132"},{"doi-asserted-by":"publisher","key":"37","DOI":"10.1038\/nature11922"},{"doi-asserted-by":"publisher","key":"38","DOI":"10.1016\/j.neuron.2016.09.050"},{"doi-asserted-by":"publisher","key":"39","DOI":"10.1007\/s00223-017-0269-0"},{"doi-asserted-by":"publisher","key":"40","DOI":"10.1016\/j.neurobiolaging.2014.01.152"},{"doi-asserted-by":"publisher","key":"41","DOI":"10.1093\/emboj\/cdg634"},{"doi-asserted-by":"publisher","key":"42","DOI":"10.1016\/j.neures.2007.08.017"},{"doi-asserted-by":"publisher","key":"43","DOI":"10.1002\/jnr.22397"},{"doi-asserted-by":"publisher","key":"44","DOI":"10.1016\/j.brainres.2007.02.087"},{"doi-asserted-by":"publisher","key":"45","DOI":"10.1016\/j.nbd.2019.104648"},{"doi-asserted-by":"publisher","key":"46","DOI":"10.1186\/s40478-019-0874-4"},{"doi-asserted-by":"publisher","key":"47","DOI":"10.1083\/jcb.201002047"},{"doi-asserted-by":"publisher","key":"48","DOI":"10.1523\/JNEUROSCI.4428-12.2013"},{"doi-asserted-by":"publisher","key":"49","DOI":"10.3390\/ijms151222918"},{"doi-asserted-by":"publisher","key":"50","DOI":"10.1159\/000332968"},{"doi-asserted-by":"publisher","key":"51","DOI":"10.1002\/1873-3468.13506"},{"doi-asserted-by":"publisher","key":"52","DOI":"10.1038\/ng.440"},{"doi-asserted-by":"publisher","key":"53","DOI":"10.1001\/jama.2010.574"},{"doi-asserted-by":"publisher","key":"54","DOI":"10.1038\/ng1009-1047"},{"doi-asserted-by":"publisher","key":"55","DOI":"10.1007\/s43032-019-00006-7"},{"doi-asserted-by":"publisher","key":"56","DOI":"10.1016\/j.cels.2017.08.013"},{"doi-asserted-by":"publisher","key":"57","DOI":"10.1002\/humu.23271"},{"doi-asserted-by":"publisher","key":"58","DOI":"10.1071\/RD18339"},{"doi-asserted-by":"publisher","key":"59","DOI":"10.3324\/haematol.2018.207787"},{"doi-asserted-by":"publisher","key":"60","DOI":"10.3389\/fimmu.2019.00395"},{"doi-asserted-by":"publisher","key":"61","DOI":"10.1007\/s12185-017-2223-3"},{"doi-asserted-by":"publisher","key":"62","DOI":"10.1111\/1346-8138.15177"},{"doi-asserted-by":"publisher","key":"63","DOI":"10.1182\/blood-2016-12-753830"},{"doi-asserted-by":"publisher","key":"64","DOI":"10.1160\/TH16-01-0045"}],"container-title":["Computational and Mathematical Methods in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2021\/5526179.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2021\/5526179.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2021\/5526179.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T22:21:52Z","timestamp":1618611712000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cmmm\/2021\/5526179\/"}},"subtitle":[],"editor":[{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2021,4,15]]},"references-count":64,"alternative-id":["5526179","5526179"],"URL":"https:\/\/doi.org\/10.1155\/2021\/5526179","relation":{},"ISSN":["1748-6718","1748-670X"],"issn-type":[{"type":"electronic","value":"1748-6718"},{"type":"print","value":"1748-670X"}],"subject":[],"published":{"date-parts":[[2021,4,15]]}}}