{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:42:03Z","timestamp":1747190523834,"version":"3.40.5"},"reference-count":15,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T00:00:00Z","timestamp":1618790400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2021,4,19]]},"abstract":"<jats:p>The t(7;11)(p15;p15) translocation is a recurrent genetic abnormality associated with acute myelogenous leukemia (AML). The translocation results in a fusion between the nucleoporin 98 and homeobox genes. We describe a case of AML with t(7; 7)(p15;p22) translocation, which is a novel simple variant of the t(7;11)(p15;p15) translocation. A 66-year-old woman presented with subcutaneous hemorrhage in both forearms. Laboratory test revealed hyperleukocytosis (white blood cell count: 97,800 cells\/\u00b5L (blasts, 51.0%)), anemia (hemoglobin level: 7.6\u2009g\/dL), thrombocytopenia (platelet count: 6.5\u2009\u00d7\u2009104\/\u03bcL), and hyperfibrinolysis (elevated d-dimer level: 12.4\u2009\u00b5g\/mL; fibrin\/fibrinogen degradation products: 26.9\u2009\u00b5g\/mL). The patient was diagnosed with AML; the blast morphology was unclassifiable according to the French-American-British classification. Flow cytometry CD45 gating revealed that the blasts expressed CD34, CD13, CD33, and CD117. G-banding of tumor cells revealed the t(7;7)(p15;p22) translocation [20\/20]. The patient underwent chemotherapy. At 48 days of admission, the patient died of multiple organ failure. The t(7;7)(p15;p22) translocation involved chromosome 7p15, indicating its association with the homeobox genes. To the best of our knowledge, this is the first report of a patient with AML with the t(7\u037e7)(p15\u037ep22) translocation, which is a simple novel variant of the t(7\u037e11)(p15\u037ep15) translocation.<\/jats:p>","DOI":"10.1155\/2021\/5529669","type":"journal-article","created":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T01:50:37Z","timestamp":1618969837000},"page":"1-4","source":"Crossref","is-referenced-by-count":0,"title":["Acute Myelogenous Leukemia with the t(7;7)(p15;p22) Translocation, a Novel Simple Variant of t(7;11)(p15;p15) Translocation: First Description"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4696-0405","authenticated-orcid":true,"given":"Motoharu","family":"Shibusawa","sequence":"first","affiliation":[{"name":"IMS Group, Shinmatsudo Central General Hospital, Department of Hematology, Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","article-title":"Acute myeloid leukaemia with recurrent genetic abnormalities","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"D. 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