{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:48:07Z","timestamp":1790603287673,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T00:00:00Z","timestamp":1621987200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012021","name":"Iran University of Medical Sciences","doi-asserted-by":"publisher","award":["94-01-28-25836"],"award-info":[{"award-number":["94-01-28-25836"]}],"id":[{"id":"10.13039\/100012021","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sarem Fertility and Infertility Research Center","award":["94-01-28-25836"],"award-info":[{"award-number":["94-01-28-25836"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Research and Management"],"published-print":{"date-parts":[[2021,5,26]]},"abstract":"<jats:p>\n                    Background. Endometriosis is a chronic and estrogen-dependent pelvic inflammatory disease, which may have various causes, such as oxidative stress. Dysmenorrhea, dyspareunia, and pelvic pain are well-known symptoms of endometriosis. The present clinical trial assessed the role of supplementation with antioxidant vitamins on the indices of oxidative stress as well as the severity of pain in women with endometriosis. Materials and Methods. We enrolled 60 reproductive-aged (15\u201345 years) women with pelvic pain in this triple-blind clinical trial. They had 1\u20133 stages of laparoscopic-proven endometriosis. The participants were randomized to group A (n\u2009=\u200930), given vitamin C (1000\u2009mg\/day, 2 tablets of 500\u2009mg each) and vitamin E (800\u2009IU\/day, 2 tablets of 400\u2009IU each) combination, or group B (n\u2009=\u200930), given placebo pills daily for 8 weeks. Results. Following treatment with vitamin C and vitamin E, we found a significant reduction in MDA and ROS compared with the placebo group. There was no significant decline in total antioxidant capacity after treatment. However, the severity of pelvic pain (\n                    <jats:inline-formula>\n                      <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                      <\/a:math>\n                    <\/jats:inline-formula>\n                    value &lt;0.001), dysmenorrhea (\n                    <jats:inline-formula>\n                      <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                      <\/c:math>\n                    <\/jats:inline-formula>\n                    value &lt;0.001), and dyspareunia (\n                    <jats:inline-formula>\n                      <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>p<\/e:mi>\n                      <\/e:math>\n                    <\/jats:inline-formula>\n                    value &lt;0.001) significantly decreased in the treatment group after 8 weeks of supplementation. Conclusions. The present findings support the potential role of antioxidants in the management of endometriosis. The intake of vitamin C and vitamin E supplements effectively reduced dysmenorrhea severity and improved dyspareunia and severity of pelvic pain.\n                  <\/jats:p>","DOI":"10.1155\/2021\/5529741","type":"journal-article","created":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T18:05:06Z","timestamp":1622052306000},"page":"1-6","source":"Crossref","is-referenced-by-count":142,"title":["The Effect of Combined Vitamin C and Vitamin E Supplementation on Oxidative Stress Markers in Women with Endometriosis: A Randomized, Triple-Blind Placebo-Controlled Clinical Trial"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5758-9157","authenticated-orcid":true,"given":"Leila","family":"Amini","sequence":"first","affiliation":[{"name":"Nursing Care Research Center (NCRC), Iran University of Medical Sciences, Tehran, Iran"},{"name":"Department of Midwifery and Reproductive Health, School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7847-9961","authenticated-orcid":true,"given":"Razieh","family":"Chekini","sequence":"additional","affiliation":[{"name":"School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Reza","family":"Nateghi","sequence":"additional","affiliation":[{"name":"Sarem Fertility & Infertility Research Center (SAFIR), Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Haghani","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, School of Public Health, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tannaz","family":"Jamialahmadi","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology, Quchan Branch, Islamic Azad University, Quchan, Iran"},{"name":"Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thozhukat","family":"Sathyapalan","sequence":"additional","affiliation":[{"name":"Academic Diabetes Endocrinology and Metabolism, Hull York Medical School, University of Hull, United Kingdom of Great Britain and Northern Ireland, Hull, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8656-1444","authenticated-orcid":true,"given":"Amirhossein","family":"Sahebkar","sequence":"additional","affiliation":[{"name":"Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran"},{"name":"Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran"},{"name":"School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17403-5"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-012-2357-8"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.4103\/0974-1208.138874"},{"key":"4","volume-title":"Berek & Novak\u2019s Gynecology","author":"J. 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