{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T19:50:00Z","timestamp":1778183400775,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T00:00:00Z","timestamp":1623196800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903916"],"award-info":[{"award-number":["81903916"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2021,6,9]]},"abstract":"<jats:p>Several studies showed that IL-17A was significantly increased in nasal polyps (NPs). However, the source and characteristics of IL-17A-producing cells in NPs were not fully understood. We isolated mononuclear cells from NPs and uncinate tissues and analyzed them using flow cytometry. The results indicated that IL-17A was increased in NP tissues compared to uncinate tissues. The main IL-17A-expressing cells were CD3+ T cells in NP tissues, including Th17 cells, Tc17 cells, and \u03b3\u03b4T17 cells. Not similar to those in uncinate tissues, the majority of Th17 cells highly coexpressed IFN-\u03b3 in NP tissues, such as Th17\/1 cells, which highly expressed CXCR3, CCR6, ROR\u03b3t, and T-bet. Furthermore, Th17\/1-biased environment increased the response of nasal epithelial cells to bacterial and viral stimuli, implying that Th17\/1 cells play a greater role in the pathological development of NPs than Th17 or Th1 cells.<\/jats:p>","DOI":"10.1155\/2021\/5531606","type":"journal-article","created":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T20:05:14Z","timestamp":1623355514000},"page":"1-11","source":"Crossref","is-referenced-by-count":1,"title":["Th17\/1-Biased Inflammatory Environment Involved in the Response of Epithelial Cells to Antigen Stimuli in Nasal Polyps"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0149-4164","authenticated-orcid":true,"given":"Guangfu","family":"Xu","sequence":"first","affiliation":[{"name":"Medical College of China Three Gorges University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4662-4690","authenticated-orcid":true,"given":"Silong","family":"Chen","sequence":"additional","affiliation":[{"name":"Medical College of China Three Gorges University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1667-5080","authenticated-orcid":true,"given":"Yuchun","family":"Dong","sequence":"additional","affiliation":[{"name":"The Department of Otolaryngology, ChangYang People\u2019s Hospital, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3627-2513","authenticated-orcid":true,"given":"Li","family":"Xiao","sequence":"additional","affiliation":[{"name":"Medical College of China Three Gorges University, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","article-title":"Nasal polyps","author":"T. 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