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One of its main barriers is communication with others since it could lead to their social exclusion and frustration. To overcome this issue, this paper presents a system to interpret the Spanish sign language alphabet which makes the communication possible in those cases, where it is necessary to sign proper nouns such as names, streets, or trademarks. For this, firstly, we have generated an image dataset of the signed 30 letters composing the Spanish alphabet. Then, given that there are static and in\u2010motion letters, two different kinds of neural networks have been tested and compared: convolutional neural networks (CNNs) and recurrent neural networks (RNNs). A comparative analysis of the experimental results highlights the importance of the spatial dimension with respect to the temporal dimension in sign interpretation. 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