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There is no doubt that blood is deemed one of the vital relief supplies, and ensuring smooth blood delivery may substantially alleviate subsequent impacts caused by the disaster. Taking red blood cell products as the research object, this work proposes a four\u2010echelon blood supply chain model. Specifically, it includes blood donors, blood donation houses, blood centres, and hospitals. Furthermore, numerical analysis is provided to test the feasibility of blood collection and distribution schemes and conduct sensitivity analysis to test the impacts of the relevant parameters (e.g., apheresis donation proportion of red blood cells (RBCs), distance between blood donors and blood facilities, and times of blood donation) on the scheme. 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