{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:01:38Z","timestamp":1767168098627,"version":"build-2238731810"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T00:00:00Z","timestamp":1624406400000},"content-version":"vor","delay-in-days":173,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2017CFB177"],"award-info":[{"award-number":["2017CFB177"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["7172108"],"award-info":[{"award-number":["7172108"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002799","name":"Capital Medical University","doi-asserted-by":"publisher","award":["2016fmzlwk"],"award-info":[{"award-number":["2016fmzlwk"]}],"id":[{"id":"10.13039\/501100002799","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009601","name":"Beijing Municipal Administration of Hospitals","doi-asserted-by":"publisher","award":["DFL20180701"],"award-info":[{"award-number":["DFL20180701"]}],"id":[{"id":"10.13039\/501100009601","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    . The mainstay of treatment for advanced ovarian cancer is debulking surgery followed by chemotherapy that includes carboplatin and paclitaxel, but the prognosis is poor. This study is aimed at evaluating the efficacy and safety of cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy (CRS+HIPEC) as first\u2010line surgical treatment in patients with advanced ovarian cancer (AOC).\n                    <jats:italic>Methods<\/jats:italic>\n                    . FIGO stage III\/IV AOC patients underwent CRS+HIPEC as first\u2010line surgical treatment at our center from December 2007 to January 2020. The primary endpoint was survival, and the secondary endpoint was safety.\n                    <jats:italic>Results<\/jats:italic>\n                    . Among 100 patients, the median Karnofsky performance status (KPS) score was 80 (50\u2010100), median peritoneal cancer index (PCI) was 19 (1\u201039), median completeness of cytoreduction (CC) score was 1 (0\u20103), number of organ regions removed was 4 (3\u20109), number of peritoneal regions removed was 4 (1\u20109), and number of anastomoses was 1 (0\u20104). The median follow\u2010up was 36.8 months; 75 (75.0%) patients were still alive, and 25 (25.0%) had died. The median overall survival (mOS) was 87.6 (95% CI: 72.1\u2010103.0) months, and the 1\u2010, 2\u2010, 3\u2010, 4\u2010, and 5\u2010year survival rates were 94.1%, 77.2%, 68.2%, 64.2%, and 64.2%, respectively. Univariate analysis showed that better mOS correlated with an age \u2264, KPS \u2265 80, ascites \u2264 1000\u2009ml, PCI &lt; 19, and CC score 0\u20101. Multivariate Cox analysis showed that CC was an independent factor for OS; patients who underwent CRS with a CC score 0\u20101 had a mPFS of 67.8 (95% CI: 48.3\u201087.4) months. The perioperative serious adverse event and morbidity rates were 4.0% and 2.0%, respectively.\n                    <jats:italic>Conclusions<\/jats:italic>\n                    . CRS+HIPEC improves survival for AOC patients with acceptable safety at experienced high\u2010volume centers. Stringent patient selection and complete CRS are key factors for better survival.\n                  <\/jats:p>","DOI":"10.1155\/2021\/5533134","type":"journal-article","created":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T13:50:12Z","timestamp":1624456212000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Cytoreductive Surgery plus Hyperthermic Intraperitoneal Chemotherapy Improves Survival with Acceptable Safety for Advanced Ovarian Cancer: A Clinical Study of 100 Patients"],"prefix":"10.1155","volume":"2021","author":[{"given":"Jue","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-bao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong-he","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ru","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-pei","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6018-6538","authenticated-orcid":false,"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,23]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21456"},{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/02656736.2017.1371341"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.24813"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/ajco.12449"},{"key":"e_1_2_14_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx754"},{"key":"e_1_2_14_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2016.05.010"},{"key":"e_1_2_14_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2018.05.006"},{"key":"e_1_2_14_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0b013e32831f8f32"},{"key":"e_1_2_14_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2013.09.030"},{"key":"e_1_2_14_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1708618"},{"key":"e_1_2_14_11_2","volume-title":"Ovarian cancer","author":"NCCN guidelines","year":"2019"},{"key":"e_1_2_14_12_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i30.6906"},{"key":"e_1_2_14_13_2","first-page":"219","article-title":"Dendrimer-paclitaxel complexes for efficient treatment in ovarian cancer: study on OVCAR-3 and HEK293T cells","volume":"65","author":"Yao H.","year":"2019","journal-title":"Acta Biochimica Polonica"},{"key":"e_1_2_14_14_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2015-0500"},{"key":"e_1_2_14_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-018-0703-0"},{"key":"e_1_2_14_16_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-018-6464-z"},{"key":"e_1_2_14_17_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-018-6631-2"},{"key":"e_1_2_14_18_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.17497"},{"key":"e_1_2_14_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2018.10.528"},{"key":"e_1_2_14_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2019.06.021"},{"key":"e_1_2_14_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40814-018-0283-7"},{"key":"e_1_2_14_22_2","article-title":"Intraperitoneal chemotherapy for the initial management of primary epithelial ovarian cancer","volume":"1","author":"Jaaback K.","year":"2016","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_14_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.25703"},{"key":"e_1_2_14_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-017-3376-8"},{"key":"e_1_2_14_25_2","doi-asserted-by":"publisher","DOI":"10.1080\/02656736.2017.1283066"},{"key":"e_1_2_14_26_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2015-0486"},{"key":"e_1_2_14_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13193-016-0501-9"},{"key":"e_1_2_14_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000000809"},{"key":"e_1_2_14_29_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-3599-4"},{"key":"e_1_2_14_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2013.08.013"},{"key":"e_1_2_14_31_2","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2015.26.1.54"},{"key":"e_1_2_14_32_2","first-page":"1176","article-title":"Prognostic factors and outcomes of cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy in patients with advanced ovarian cancer - a single tertiary institution experience","volume":"21","author":"Kocic M.","year":"2016","journal-title":"Journal of BUON"},{"key":"e_1_2_14_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2016.02.002"},{"key":"e_1_2_14_34_2","doi-asserted-by":"publisher","DOI":"10.23736\/S0026-4784.16.03959-9"},{"key":"e_1_2_14_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.24666"},{"key":"e_1_2_14_36_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5686-1"},{"key":"e_1_2_14_37_2","unstructured":"National cancer institute Common terminology critertia for adverse events (CTCAE) v5.0 2017 https:\/\/ctep.cancer.gov\/protocolDevelopment\/electronic_applications\/ctc.htm#ctc_50."}],"updated-by":[{"DOI":"10.1155\/2021\/9789613","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T00:00:00Z","timestamp":1630281600000}}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2021\/5533134.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2021\/5533134.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2021\/5533134","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T02:19:02Z","timestamp":1735611542000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2021\/5533134"}},"subtitle":[],"editor":[{"given":"Qiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1155\/2021\/5533134"],"URL":"https:\/\/doi.org\/10.1155\/2021\/5533134","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"2021-01-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"5533134"}}