{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:06:24Z","timestamp":1792195584375,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,3,28]],"date-time":"2021-03-28T00:00:00Z","timestamp":1616889600000},"content-version":"vor","delay-in-days":86,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31972599"],"award-info":[{"award-number":["31972599"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n                    This study elucidated the function role of dietary selenium\u2010enriched yeast (SeY) supplementation on growth performance, immune function, and antioxidant capacity in weaned pigs exposure to oxidative stress. Thirty\u2010two similarity weight pigs were randomly divided into four treatments: (1) nonchallenged control, (2) control+SeY, (3) control+diquat, and (4) control+SeY+diquat. The period of experiment was 21 days; on day 16, pigs were injected with diquat or sterile saline. Results revealed that oxidative stress was notably detrimental to the growth performance of piglets, but SeY supplementation ameliorated this phenomenon, which might be regarding the increasing of body antioxidant capacity and immune functions. In details, SeY supplementation improved the digestibility of crude protein (CP), ash, and gross energy (GE). Moreover, the serum concentrations of proinflammatory cytokines (TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    , IL\u20101\n                    <jats:italic>\u03b2<\/jats:italic>\n                    , and IL\u20106), glutamic\u2010pyruvic transaminase(GPT), and glutamic\u2010oxaloacetic transaminase (GOT) were reduced via SeY supplemented, and serum concentrations of immunoglobulins A (IgA), IgG, and activities of antioxidant enzymes such as the superoxide dismutase (SOD), catalase (CAT) ,and glutathione peroxidase (GSH\u2010Px) were improved in the diquat\u2010challenged pigs (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05). In addition, SeY supplementation acutely enhanced the activities of these antioxidant enzymes in the liver and thymus upon diquat challenge, which involved with the upregulation of the critical genes related antioxidant signaling such as the nuclear factor erythroid\u2010derived 2\u2010related factor 2 (Nrf\u20102) and heme oxygenase\u20101 (HO\u20101) (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05). Importantly, we also found that SeY supplementation apparently reduced the malondialdehyde (MDA) concentrations in the liver, thymus, and serum (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05). Specifically, the expression levels of TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    , IL\u20106, IL\u20101\n                    <jats:italic>\u03b2<\/jats:italic>\n                    , Toll\u2010like receptor 4 (TLR\u20104), and nuclear factor\u2010\n                    <jats:italic>\u03ba<\/jats:italic>\n                    B (NF\u2010\n                    <jats:italic>\u03ba<\/jats:italic>\n                    B) in the liver and thymus were downregulated by SeY upon diquat challenge. These results suggested that SeY can attenuate oxidative stress\u2010induced growth retardation, which was associated with elevating body antioxidant capacity, immune functions, and suppressed inflammatory response.\n                  <\/jats:p>","DOI":"10.1155\/2021\/5533210","type":"journal-article","created":{"date-parts":[[2021,3,28]],"date-time":"2021-03-28T14:05:07Z","timestamp":1616940307000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Influences of Selenium\u2010Enriched Yeast on Growth Performance, Immune Function, and Antioxidant Capacity in Weaned Pigs Exposure to Oxidative Stress"],"prefix":"10.1155","volume":"2021","author":[{"given":"Lei","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiwen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuheng","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangbing","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junqiu","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1963-9766","authenticated-orcid":false,"given":"Jun","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,28]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.2527\/2002.802494x"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00081.2009"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.5567\/pharmacologia.2015.11.20"},{"key":"e_1_2_11_4_2","first-page":"1222","article-title":"Polymorphisms in the oxidative stress genes, superoxide dismutase, glutathione peroxidase and catalase and risk of non-Hodgkin\u2032s lymphoma","volume":"91","author":"Lightfoot T. 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