{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T21:21:45Z","timestamp":1792185705383,"version":"4.4.0"},"reference-count":56,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T00:00:00Z","timestamp":1619568000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004386","name":"Universiti Malaya","doi-asserted-by":"publisher","award":["UM.C\/625\/1\/HIR\/MOHE\/MED\/28"],"award-info":[{"award-number":["UM.C\/625\/1\/HIR\/MOHE\/MED\/28"]}],"id":[{"id":"10.13039\/501100004386","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2021,4,28]]},"abstract":"<jats:p>Background. Adipocytokines participate in regulating the inflammatory response in glucose homeostasis and type 2 diabetes. However, among these peptides, the role of adipocyte-specific fatty-acid-binding protein (AFABP), chemerin, and secreted protein acidic and rich in cysteine (SPARC) in gestational diabetes (GDM) has not been fully investigated. Method. The maternal fasting level of adipocytokines of 53 subjects with GDM and 43 normal pregnant (NGDM) was measured using multiplex immunoassay at 24\u201328 weeks, before delivery, immediate postpartum, and 2\u20136 months postpuerperium. Results. Higher levels of AFABP were associated with a 3.7-fold higher risk of GDM. Low chemerin levels were associated with a 3.6-fold higher risk of GDM. Interleukin-10 (IL-10) was inversely associated with the risk of GDM. SPARC had no association with GDM. AFABP was directly correlated to interleukin-6 (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>r<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.50<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>), insulin resistance index (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>r<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.26<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>), and body mass index (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>r<\/e:mi>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>0.28<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>) and inversely correlated to C-reactive protein (<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>r<\/g:mi>\n                        <g:mo>=<\/g:mo>\n                        <g:mo>\u2212<\/g:mo>\n                        <g:mn>0.27<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>). Chemerin levels were directly and strongly correlated with IL-10 (<jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>r<\/i:mi>\n                        <i:mo>=<\/i:mo>\n                        <i:mn>0.41<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>) and interleukin-4 (<jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mi>r<\/k:mi>\n                        <k:mo>=<\/k:mo>\n                        <k:mn>0.50<\/k:mn>\n                     <\/k:math>\n                  <\/jats:inline-formula>) and inversely correlated to insulin resistance index (<jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mi>r<\/m:mi>\n                        <m:mo>=<\/m:mo>\n                        <m:mo>\u2212<\/m:mo>\n                        <m:mn>0.23<\/m:mn>\n                     <\/m:math>\n                  <\/jats:inline-formula>) in GDM but not NGDM. In the longitudinal assessment, there were no significant differences in AFABP and chemerin concentrations of both studied groups. Conclusion. AFABP and chemerin were associated with a higher risk of GDM. These adipocytokines were related to insulin resistance, body mass index, and inflammation in pregnant women diagnosed with GDM.<\/jats:p>","DOI":"10.1155\/2021\/5533802","type":"journal-article","created":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T23:09:28Z","timestamp":1619651368000},"page":"1-7","source":"Crossref","is-referenced-by-count":6,"title":["Adipocyte-Specific Fatty Acid-Binding Protein (AFABP) and Chemerin in Association with Gestational Diabetes: A Case-Control Study"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2177-4470","authenticated-orcid":true,"given":"Maryam","family":"Mosavat","sequence":"first","affiliation":[{"name":"Department of Obstetrics & Gynecology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitra","family":"Mirsanjari","sequence":"additional","affiliation":[{"name":"Mazandaran University of Medical Sciences, Emam Khomeini Hospital, Fereidonkenar, Mazandaran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5748-4892","authenticated-orcid":true,"given":"Bashir A.","family":"Lwaleed","sequence":"additional","affiliation":[{"name":"School of Health Sciences at the University of Southampton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7396-4087","authenticated-orcid":true,"given":"Maherah","family":"Kamarudin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1646-9869","authenticated-orcid":true,"given":"Siti Zawiah","family":"Omar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.5603\/EP.2014.0019"},{"key":"2","first-page":"49","article-title":"Adipose tissue as a source of proinflammatory factors in obesity: the importance in the development of insulin resistance and diabetes","volume":"9","author":"M. 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