{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T12:05:18Z","timestamp":1774440318226,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T00:00:00Z","timestamp":1619395200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2021,4,26]]},"abstract":"<jats:p>Waltheria indica L. (Malvaceae) is a plant used in Burkina Faso for the treatment of various ailments including asthma. The aim of the study was to evaluate the pharmacological relaxant effect of the leafy stem extracts of Waltheria indica and thereby verify claim of use in treating asthma. Aqueous decoction and hydroalcoholic extracts obtained from the powdered leafy stems were screened for the presence of some phytoconstituents. The in vitro relaxant effect of the two extracts was evaluated on acetylcholine- (ACh 10\u22125\u2009M) and potassium chloride- (KCl 6\u2009\u00d7\u200910\u22122\u2009M) induced contractions on rat-isolated tracheal preparations. To examine whether the potassium (K+) channels are involved in the relaxant effect, glibenclamide, an ATP-sensitive potassium channel inhibitor, was used. Moreover, to assess the safety of the extracts, acute oral toxicity was carried out on mice. The phytochemical screening revealed the presence of alkaloids, flavonoids, saponins, steroids, triterpenoids, tannins, and coumarins in the hydroalcoholic extract. Tannins, steroids, triterpenoids, and coumarins were not detected in the aqueous decoction. With respective EC50 values of 1.517\u2009\u00b1\u20090.002\u2009mg\/mL and 1.433\u2009\u00b1\u20090.001\u2009mg\/mL on ACh-and KCl-provoked contractions, the hydroalcoholic extract was found more potent in relaxing the isolated rat tracheal preparations compared to the aqueous decoction. In the presence of glibenclamide, the relaxant effect of the hydroalcoholic extract (EC50\u2009=\u20090.191\u2009\u00b1\u20090.002\u2009mg\/mL) increased and was higher than that of the aqueous decoction. At dose of 5000\u2009mg\/kg of body weight, the extracts did not produce deaths or any significant changes in the general behavior of mice. The results suggest that different mechanisms including modulation of calcium and potassium channels, particularly the ATP-sensitive K+ channels, could be involved in the relaxation effect. These findings could justify the traditional use of W. indica in the management of asthma.<\/jats:p>","DOI":"10.1155\/2021\/5535727","type":"journal-article","created":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T19:00:38Z","timestamp":1619550038000},"page":"1-8","source":"Crossref","is-referenced-by-count":5,"title":["Pharmacological Evaluation of the Bronchorelaxant Effect of Waltheria indica L. (Malvaceae) Extracts on Rat Trachea"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3014-7874","authenticated-orcid":true,"given":"Rainatou","family":"Boly","sequence":"first","affiliation":[{"name":"Institute of Research in Health Science (IRSS), 03 PO 7047, Ouagadougou 03, Burkina Faso"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zakaline","family":"Yabre","sequence":"additional","affiliation":[{"name":"Laboratory of Drug Development, Doctoral School of Sciences and Health, University Joseph KI-ZERBO, 03 BP 7021, Ouagadougou 03, Burkina Faso"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2376-2927","authenticated-orcid":true,"given":"Mathieu","family":"Nitiema","sequence":"additional","affiliation":[{"name":"Institute of Research in Health Science (IRSS), 03 PO 7047, Ouagadougou 03, Burkina Faso"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boubacar","family":"Yaro","sequence":"additional","affiliation":[{"name":"Institute of Research in Health Science (IRSS), 03 PO 7047, Ouagadougou 03, Burkina Faso"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jules","family":"Yoda","sequence":"additional","affiliation":[{"name":"Institute of Research in Health Science (IRSS), 03 PO 7047, Ouagadougou 03, Burkina Faso"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4519-2603","authenticated-orcid":true,"given":"Lazare","family":"Belemnaba","sequence":"additional","affiliation":[{"name":"Institute of Research in Health Science (IRSS), 03 PO 7047, Ouagadougou 03, Burkina Faso"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvain","family":"Ilboudo","sequence":"additional","affiliation":[{"name":"Institute of Research in Health Science (IRSS), 03 PO 7047, Ouagadougou 03, Burkina Faso"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"No\u00ebla Hoho Estelle","family":"Youl","sequence":"additional","affiliation":[{"name":"Laboratory of Drug Development, Doctoral School of Sciences and Health, University Joseph KI-ZERBO, 03 BP 7021, Ouagadougou 03, Burkina Faso"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Innocent Pierre","family":"Guissou","sequence":"additional","affiliation":[{"name":"University of Saint Thomas D\u2019Aquin, 06 PO 10212, Ouagadougou 06, Burkina Faso"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvin","family":"Ouedraogo","sequence":"additional","affiliation":[{"name":"Institute of Research in Health Science (IRSS), 03 PO 7047, Ouagadougou 03, Burkina Faso"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","article-title":"Global strategy for asthma management and prevention","author":"Global Initiative for Asthma","year":"2020"},{"key":"2","article-title":"Asthma","author":"World Health Organization","year":"2020"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/1021258"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2019.00246"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g5517"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.01.00252501"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1186\/s40816-015-0005-0"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21557"},{"issue":"12","key":"9","first-page":"1823","article-title":"Prevalence of asthma and its management: a review","volume":"68","author":"A. 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