{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:18:29Z","timestamp":1740140309755,"version":"3.37.3"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T00:00:00Z","timestamp":1623196800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005891","name":"State Administration of Traditional Chinese Medicine of the People's Republic of China","doi-asserted-by":"publisher","award":["81974556"],"award-info":[{"award-number":["81974556"]}],"id":[{"id":"10.13039\/501100005891","id-type":"DOI","asserted-by":"publisher"}]},{"name":"\u201cQihuang Scholars\u201d Project","award":["81974556"],"award-info":[{"award-number":["81974556"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974556"],"award-info":[{"award-number":["81974556"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2021,6,9]]},"abstract":"<jats:p>Objective. The aim of this meta-analysis was to systematically evaluate the effectiveness and safety of the traditional Chinese medicine (TCM) formula Bushen Huoxue Decoction (BSHXD) in treating coronary heart disease (CHD). Methods. Randomized controlled trials (RCTS) of BSHXD in treating CHD were searched until March 2020, through six electronic databases: PubMed, Cochrane Library, CNKI, WanFang, SinoMed, and VIP. This study used the Cochrane Risk Test bias tool in the Cochrane Handbook to assess the quality of the methodology. Review Manager (RevMan) 5.3 was used to analyze the results. Grading of Recommendations Assessment, Development, and Evaluation (GRADE) criteria were applied in the classification of evidence quality. Results. Ten RCTs involving 901 patients were finally included in this meta-analysis. It revealed that the effectiveness of BSHXD in treating CHD was significantly better than that of the conventional western medicine (CWM) treatment (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.00001<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). The effective rate of BSHXD treatment group on ECG was also significantly higher than that of CWM group (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.00001<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). The low-density lipoprotein cholesterol was decreased in the treatment groups compared with those in the control groups (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.00001<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>). There was also a reduction in frequency and duration of angina pectoris (<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>&lt;<\/g:mo>\n                        <g:mn>0.00001<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>). There were no significant differences in TC level (<jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>P<\/i:mi>\n                        <i:mo>=<\/i:mo>\n                        <i:mn>0.08<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>), TG level (<jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mi>P<\/k:mi>\n                        <k:mo>=<\/k:mo>\n                        <k:mn>0.86<\/k:mn>\n                     <\/k:math>\n                  <\/jats:inline-formula>), and HDL level (<jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mi>P<\/m:mi>\n                        <m:mo>=<\/m:mo>\n                        <m:mn>0.76<\/m:mn>\n                     <\/m:math>\n                  <\/jats:inline-formula>) between the treatment and control groups. Five studies had informed adverse events, including nausea and diarrhea. Conclusion. Our findings laid the foundation to the use of TCM Formula BSHXD in combination with conventional western medicine for treating CHD. However, due to the limitation of the quality of the included researches, in addition to potential reporting bias, the above conclusions still need verification by higher-quality and better-designed studies.<\/jats:p>","DOI":"10.1155\/2021\/5541228","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T19:36:41Z","timestamp":1623267401000},"page":"1-14","source":"Crossref","is-referenced-by-count":4,"title":["The Effectiveness and Safety of Bushen Huoxue Decoction on Treating Coronary Heart Disease: A Meta-Analysis"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2093-7664","authenticated-orcid":true,"given":"Lan-Chun","family":"Liu","sequence":"first","affiliation":[{"name":"Cardiovascular Department, Guang\u2019anmen Hospital of China Academy of Chinese Medical Sciences, Beijing, China"},{"name":"Beijing University of Chinese Medicine, Beijing 100029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3686-2847","authenticated-orcid":true,"given":"Qi-Yuan","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Oncology, Guang\u2019anmen Hospital of China Academy of Chinese Medical Sciences, Beijing, China"},{"name":"Beijing University of Chinese Medicine, Beijing 100029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1806-9930","authenticated-orcid":true,"given":"Chao","family":"Liu","sequence":"additional","affiliation":[{"name":"Cardiovascular Department, Guang\u2019anmen Hospital of China Academy of Chinese Medical Sciences, Beijing, China"},{"name":"Beijing University of Chinese Medicine, Beijing 100029, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7569-3433","authenticated-orcid":true,"given":"Jun","family":"Hu","sequence":"additional","affiliation":[{"name":"Cardiovascular Department, Guang\u2019anmen Hospital of China Academy of Chinese Medical Sciences, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8561-5212","authenticated-orcid":true,"given":"Lian","family":"Duan","sequence":"additional","affiliation":[{"name":"Cardiovascular Department, Guang\u2019anmen Hospital of China Academy of Chinese Medical Sciences, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2178-5148","authenticated-orcid":true,"given":"Jie","family":"Wang","sequence":"additional","affiliation":[{"name":"Cardiovascular Department, Guang\u2019anmen Hospital of China Academy of Chinese Medical Sciences, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"volume-title":"Cardiovascular Diseases","year":"2017","author":"World Health Organization","key":"1"},{"key":"2","first-page":"284","volume-title":"China Health Statistics Year 2019 Edition","author":"National Health Commission","year":"2019"},{"issue":"3","key":"3","first-page":"209","article-title":"Chinese cardiovascular disease report 2018 summary","volume":"34","author":"S. S. Hu","year":"2019","journal-title":"Chinese Journal of Circulation"},{"issue":"10","key":"4","first-page":"920","article-title":"Study on the combination of the syndrome elements and indications of coronary heart disease and angina pectoris","volume":"48","author":"J. Wang","year":"2007","journal-title":"Journal of Traditional Chinese Medicine"},{"issue":"3","key":"5","first-page":"211","article-title":"Study on the complex system entropy clustering method for 1069 cases of coronary heart disease with angina pectoris syndrome elements extraction and syndrome combination law","volume":"15","author":"J. Wang","year":"2008","journal-title":"Chinese Journal of Basic Medicine in Traditional Chinese Medicine"},{"issue":"5","key":"6","first-page":"28","article-title":"Clinical observation on 68 cases of coronary heart disease and angina treated by bushen Huoxue decoction","volume":"43","author":"X. H. Ye","year":"1998","journal-title":"New Chinese Medicine"},{"issue":"5","key":"7","first-page":"173","article-title":"Research progress on the pharmacological effects of the active ingredients of Rehmannia glutinosa","volume":"7","author":"Y. Zhu","year":"2011","journal-title":"Asia-Pacific Traditional Medicine"},{"issue":"1","key":"8","first-page":"982","article-title":"A quick reference manual for the pharmacology and clinical application of traditional Chinese medicine","volume":"12","author":"D. S. Zhou","year":"2012","journal-title":"Hunan Science and Technology Press"},{"issue":"12","key":"9","first-page":"17","article-title":"Angina pectoris and arrhythmia with integrated traditional Chinese and western medicine, \u201ccriteria for evaluating the curative effect of coronary heart disease and angina pectoris","volume":"10","author":"Symposium on Prevention and Treatment of Coronary Heart Disease","year":"1979","journal-title":"Journal of Medical Research"},{"issue":"4","key":"10","first-page":"251","article-title":"Ministry of Health, \u201cGuidelines for clinical research on cardiovascular system drugs","volume":"4","author":"Department of Pharmaceutical Administration","year":"1998","journal-title":"Chinese Journal of Clinical Pharmacology"},{"volume-title":"Guiding Principles for Clinical Research of New Traditional Chinese Medicines","year":"2002","author":"X. Y. Zheng","key":"11"},{"key":"12"},{"key":"13"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"issue":"3","key":"15","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1161\/01.CIR.59.3.607","article-title":"Nomenclature and criteria for diagnosis of ischemic heart disease. Report of the Joint International Society and Federation of Cardiology\/World Health Organization task force on standardization of clinical nomenclature","volume":"59","author":"Organization W H","year":"1979","journal-title":"Circulation"},{"issue":"2","key":"16","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.cardfail.2013.12.002","article-title":"ACCF\/AHA\/ASE\/ASNC\/HFSA\/HRS\/SCAI\/SCCT\/SCMR\/STS 2013 multimodality appropriate use criteria for the detection and risk assessment of stable ischemic heart disease","volume":"20","author":"M. J. Wolk","year":"2014","journal-title":"Journal of Cardiac Failure"},{"issue":"3","key":"17","first-page":"195","article-title":"Guidelines for the diagnosis and treatment of chronic stable angina pectoris","volume":"35","author":"Cardiovascular Branch of Chinese Medical Association","year":"2007","journal-title":"Chinese Journal of Cardiovascular Diseases"},{"issue":"7","key":"18","first-page":"53","article-title":"The short-term curative effect observation of 96 cases of unstable angina pectoris treated with integrated traditional Chinese and western medicine","volume":"23","author":"J. X. Zhang","year":"2005","journal-title":"Sichuan Traditional Chinese Medicine"},{"issue":"10","key":"19","first-page":"1315","article-title":"Observation on the long-term curative effect of integrated traditional Chinese and western medicine on unstable angina pectoris","volume":"33","author":"J. X. Zhang","year":"2006","journal-title":"Liaoning Journal of Traditional Chinese Medicine"},{"issue":"3","key":"20","first-page":"18","article-title":"A randomized controlled clinical study of 80 cases of stable Angina pectoris treated by the method of promoting blood circulation and tonifying the kidney","volume":"30","author":"C. Chen","year":"2007","journal-title":"Journal of Chengdu University of Traditional Chinese Medicine"},{"volume-title":"Study on Yishen Huoxue Decoction in the Prevention and Treatment of Restenosis after Coronary Intervention","year":"2009","author":"W. Guo","key":"21"},{"issue":"9","key":"22","first-page":"1020","article-title":"Yishen tongluo powder in treating 56 cases of postmenopausal coronary heart disease and angina pectoris","volume":"7","author":"Y. M. Liu","year":"2009","journal-title":"Journal of Integrated Traditional Chinese and Western Medicine Cardio-Cerebrovascular Disease"},{"volume-title":"Clinical Study on the Treatment of Angina Pectoris of Coronary Heart Disease with Kidney Deficiency and Blood Stasis by the Method of Invigorating the Kidney and Removing Blood Stasis","year":"2011","author":"W. J. Wang","key":"23"},{"issue":"9","key":"24","first-page":"27","article-title":"Clinical efficacy of integrated traditional Chinese and western medicine in the treatment of coronary heart disease with blood stasis syndrome in angina pectoris and its influence on blood Hcy level","volume":"44","author":"X. L. Song","year":"2012","journal-title":"Jiangsu Traditional Chinese Medicine"},{"issue":"11","key":"25","first-page":"1105","article-title":"Observation of clinical efficacy of self-made Bushen Huoxue Decoction on angina pectoris after PCI of coronary heart disease","volume":"5","author":"L. L. Gang","year":"2014","journal-title":"Journal of Difficult and Difficult Diseases"},{"issue":"5","key":"26","first-page":"21","article-title":"Clinical observation on the treatment of stable Angina pectoris of yin deficiency of heart and kidney with integrated traditional Chinese and western medicine","volume":"31","author":"W. Song","year":"2015","journal-title":"Shanxi Traditional Chinese Medicine"},{"volume-title":"Clinical Study of Bushen Huoxue Decoction in the Treatment of Recurring Angina Pectoris (Kidney Deficiency and Blood Stasis Syndrome) after PCI of Coronary Heart Disease","year":"2017","author":"W. Wang","key":"27"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a060393"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1177\/000456329903600602"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/s0272-6386(12)80859-6"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.13.5_suppl.i80"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-134-8-200104170-00007"},{"issue":"1","key":"33","first-page":"22","article-title":"American heart association scientific sessions. Best of the AHA scientific sessions 2001","volume":"3","author":"R. W. Nesto","year":"2002","journal-title":"Reviews in Cardiovascular Medicine"},{"issue":"104","key":"34","first-page":"379","article-title":"The double jeopardy of diabetes and renal insufficiency in Acute Coronary Syndromes","volume":"104","author":"A. T. Askari","year":"2001","journal-title":"Circulation"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.00773.x"},{"issue":"2","key":"36","first-page":"S1","article-title":"K\/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification","volume":"39","author":"NK Foundation","year":"2002","journal-title":"American Journal of Kidney Diseases"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2021\/5541228.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2021\/5541228.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2021\/5541228.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T19:37:25Z","timestamp":1623267445000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ecam\/2021\/5541228\/"}},"subtitle":[],"editor":[{"given":"Xue-Rui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,6,9]]},"references-count":36,"alternative-id":["5541228","5541228"],"URL":"https:\/\/doi.org\/10.1155\/2021\/5541228","relation":{},"ISSN":["1741-4288","1741-427X"],"issn-type":[{"type":"electronic","value":"1741-4288"},{"type":"print","value":"1741-427X"}],"subject":[],"published":{"date-parts":[[2021,6,9]]}}}