{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:40:59Z","timestamp":1747190459472,"version":"3.40.5"},"reference-count":19,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T00:00:00Z","timestamp":1618790400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Medicine"],"published-print":{"date-parts":[[2021,4,19]]},"abstract":"<jats:p>Denosumab is a human monoclonal antibody that binds to RANKL (receptor activator of nuclear factor-kappa B ligand). It has mainly been used in the treatment of osteoporosis for a variety of causes especially in situations refractory to bisphosphonates or when kidney function is impaired. It is also used in cases of malignancy-associated hypercalcemia. There are many causes of hypercalcemia, but only rarely it is associated with granulomatous diseases such as tuberculous pleural effusion. We report a case of hypercalcemia from tuberculous pleural effusion that was initially admitted with left medium abundance pleural effusion and a serum corrected calcium level of 3.48\u2009mmol\/L. The calcium level was successfully normalized within 72 hours of subcutaneous denosumab administration after other interventions have failed.<\/jats:p>","DOI":"10.1155\/2021\/5544848","type":"journal-article","created":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T00:15:07Z","timestamp":1618964107000},"page":"1-4","source":"Crossref","is-referenced-by-count":2,"title":["Denosumab as the Treatment of Recalcitrant Tuberculous Pleural Effusion-Associated Hypercalcemia"],"prefix":"10.1155","volume":"2021","author":[{"given":"Afdhal Afiq","family":"Abd Jalil","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4508-1436","authenticated-orcid":true,"given":"Sharifah Faradila","family":"Wan Muhamad Hatta","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia"},{"name":"Endocrine and Diabetes Unit, Department of Internal Medicine, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8299-4843","authenticated-orcid":true,"given":"Aimi Fadilah","family":"Mohamad","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia"},{"name":"Endocrine and Diabetes Unit, Department of Internal Medicine, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed Fauzi","family":"Abdul Rani","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, Selangor, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.2217\/fon.15.232"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.14740\/jmc2220w"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.4103\/2249-4863.192327"},{"issue":"10","key":"4","first-page":"818","article-title":"Hypercalcaemia in patients with newly diagnosed tuberculosis in Malaysia","volume":"2","author":"C. K. Liam","year":"1998","journal-title":"The International Journal of Tuberculosis and Lung Disease: The Official Journal of the International Union Against Tuberculosis and Lung Disease"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-90-3-324"},{"issue":"6","key":"6","first-page":"613","article-title":"The prevalence of hypercalcaemia in pulmonary and miliary tuberculosis\u2014a longitudinal study","volume":"35","author":"T. Y. Chan","year":"1994","journal-title":"Singapore Medical Journal"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1001"},{"key":"8","first-page":"113","article-title":"Denosumab in the treatment of hypercalcemia secondary to malignancy","volume":"5","author":"A. C. Dalkin","year":"2015","journal-title":"Orphan Drugs: Research and Reviews"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1210\/er.2016-1070"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1172\/jci114609"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.lab.2003.08.002"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.7860\/jcdr\/2019\/41664.13112"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1136\/bcr.10.2008.1081"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-29182-6_59"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1177\/1060028020953501"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1530\/eje-11-0454"},{"issue":"5","key":"17","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/1744-9987.12788","article-title":"Successful treatment of tuberculosis-associated hypercacemia with denosumab in a patient with acute kidney injury\u2019","volume":"23","author":"A. Torres-Ortiz","year":"2019","journal-title":"Therapeutic Apheresis and Dialysis"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2012.06.019"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2012.41.7923"}],"container-title":["Case Reports in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crim\/2021\/5544848.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crim\/2021\/5544848.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crim\/2021\/5544848.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T00:15:12Z","timestamp":1618964112000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crim\/2021\/5544848\/"}},"subtitle":[],"editor":[{"given":"Bruno","family":"Megarbane","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,4,19]]},"references-count":19,"alternative-id":["5544848","5544848"],"URL":"https:\/\/doi.org\/10.1155\/2021\/5544848","relation":{},"ISSN":["1687-9635","1687-9627"],"issn-type":[{"type":"electronic","value":"1687-9635"},{"type":"print","value":"1687-9627"}],"subject":[],"published":{"date-parts":[[2021,4,19]]}}}