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Therefore, researchers have intensified their efforts to research new alternative medicines to treat schistosomiasis. In the present study, <jats:italic>in vitro<\/jats:italic> as well as <jats:italic>in vivo<\/jats:italic> studies have been accomplished to evaluate the effect of <jats:italic>Origanum majorana<\/jats:italic>, <jats:italic>Ziziphus spina-christi<\/jats:italic>, and <jats:italic>Salvia fruticosa<\/jats:italic> extracts in a different concentration 500, 250, 125, 62.5, and 31.25\u2009<jats:italic>\u03bc<\/jats:italic>g\/ml on golden hamster infected by Egyptian strains of schistosome (<jats:italic>Schistosoma haematobium<\/jats:italic>). <jats:italic>In vitro<\/jats:italic>, the adult worms and schistosomula of <jats:italic>S. haematobium<\/jats:italic> were investigated in RPMI\u20101640 medium for 48\u2009hrs. The results showed that the concentration 500, 250, and 125\u2009<jats:italic>\u03bc<\/jats:italic>g\/ml of <jats:italic>Origanum majorana<\/jats:italic>, and <jats:italic>Ziziphus spina-christi<\/jats:italic> caused dead of 100% of Egyptian <jats:italic>Schistosoma<\/jats:italic> strains of adult worm and schistosomula of <jats:italic>S. haematobium<\/jats:italic> within 6 to 12\u2009hrs of incubation. On the other hand, the extract of <jats:italic>Salvia fruticosa<\/jats:italic> at concentrations 500, 250, and 125\u2009<jats:italic>\u03bc<\/jats:italic>g\/ml showed death 100% parasites after 12 to 24\u2009hrs of incubation. Inclusion, <jats:italic>Origanum majorana<\/jats:italic>, and <jats:italic>Ziziphus spina-christi<\/jats:italic> showed effectiveness against Egyptian <jats:italic>Schistosoma<\/jats:italic> strains (<jats:italic>S. haematobium<\/jats:italic>), a slight decrease in <jats:italic>Salvia fruticosa<\/jats:italic> was observed. Therefore, these medical plant extracts may be used as a safe and effective treatment for schistosomiasis.<\/jats:p>","DOI":"10.1155\/2021\/5545331","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T19:35:08Z","timestamp":1623699308000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Antischistosomal Activity of <i>Origanum majorana<\/i>, <i>Ziziphus spina-christi<\/i>, and <i>Salvia fruticosa<\/i> Plant Extracts on Hamster Infected with <i>Schistosoma haematobium<\/i>"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2638-624X","authenticated-orcid":false,"given":"Yousef Abdal Jalil","family":"Fadladdin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,14]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(06)70521-7"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69440-3"},{"key":"e_1_2_8_3_2","unstructured":"World Health Organization (WHO) Schistosomiasis fact sheet 2014 https:\/\/www.who.int\/mediacentre\/factsheets\/fs115\/en."},{"key":"e_1_2_8_4_2","unstructured":"World Health Organization (WHO) Schistosomiasis fact sheet 2019 https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/schistosomiasis."},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.2557.16-a"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(96)30007-0"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)10221-X"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-4758(97)01206-4"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2012.07.003"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.15.16"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40364-016-0075-2"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2014.06.002"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2012.07.004"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-002-0768-3"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(01)50032-9"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(00)00377-9"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1515\/znc-2009-11-1207"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-008-1311-y"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2010.08.021"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2011.625952"},{"key":"e_1_2_8_21_2","volume-title":"Current Topics in Tropical Medicine","author":"de Moraes J.","year":"2012"},{"key":"e_1_2_8_22_2","first-page":"621","article-title":"Antimicrobial activity of ethanolic and aqueous extracts of Sida acuta on microorganisms from skin infections","volume":"3","author":"Ekpo M. 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