{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T17:02:36Z","timestamp":1778864556581,"version":"3.51.4"},"reference-count":8,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T00:00:00Z","timestamp":1619049600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Pathology"],"published-print":{"date-parts":[[2021,4,22]]},"abstract":"<jats:p>Dysgerminoma is a malignant ovarian germ cell tumor, and unlike sex-cord stromal tumors, endocrine manifestation is considered rare. Here, we report the first case of dysgerminoma presenting precocious puberty. The patient is a 7-year-old girl who presented with a breast development in Tanner stage 3. Serum estradiol (E2) was markedly elevated while luteinizing hormone (LH) and follicle-stimulating hormone (FSH) were suppressed below the detection limit. Microscopically, the right ovarian mass displayed nests of large polygonal cells and fibrous septa which were focally concentrated by theca-like plump spindle cells. Immunohistochemistry revealed that the spindle cells expressed various steroidogenic enzymes involved in estrogen biosynthesis including P450 aromatase. The tumor was diagnosed with pure dysgerminoma with estrogen-producing functioning stroma. After the operation, serum E2 declined below the detection limit; LH and FSH returned within the normal range. This case demonstrates that even a conventional dysgerminoma can present endocrine manifestation through functioning stroma.<\/jats:p>","DOI":"10.1155\/2021\/5545645","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T23:33:21Z","timestamp":1619134401000},"page":"1-4","source":"Crossref","is-referenced-by-count":5,"title":["Dysgerminoma with Estrogen-Producing Functioning Stroma Presenting Precocious Puberty"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6130-3879","authenticated-orcid":true,"given":"Shunsuke","family":"Nagase","sequence":"first","affiliation":[{"name":"Department of Diagnostic Pathology, Juntendo University Nerima Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4129-6875","authenticated-orcid":true,"given":"Kanako","family":"Ogura","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology, Juntendo University Nerima Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Ashizawa","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology, Juntendo University Nerima Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nana","family":"Nakazawa-Tanaka","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Juntendo University Nerima Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Urao","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Juntendo University Nerima Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaharu","family":"Fukunaga","sequence":"additional","affiliation":[{"name":"Department of Pathology, Shin-Yurigaoka General Hospital, Kawasaki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuto","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironobu","family":"Sasano","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiharu","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology, Juntendo University Nerima Hospital, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","volume-title":"Diagnostic Gynecologic and Obstetric Pathology","author":"C. P. Crum","year":"2018","edition":"3rd"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-9-12-1349"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1080\/09513590601095111"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(72)90896-4"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-199807000-00011"},{"key":"6","article-title":"Tumors of the Ovary, Maldeveloped Gonads, Fallopian Tube, and Broad Ligament","volume-title":"Atlas of Tumor Pathology","author":"R. E. Scully","year":"1998"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900501)65:9<2001::AID-CNCR2820650920>3.0.CO;2-7"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e31827c6362"}],"container-title":["Case Reports in Pathology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cripa\/2021\/5545645.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cripa\/2021\/5545645.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cripa\/2021\/5545645.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T09:57:21Z","timestamp":1620727041000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cripa\/2021\/5545645\/"}},"subtitle":[],"editor":[{"given":"Janina","family":"Kulka","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,4,22]]},"references-count":8,"alternative-id":["5545645","5545645"],"URL":"https:\/\/doi.org\/10.1155\/2021\/5545645","relation":{},"ISSN":["2090-679X","2090-6781"],"issn-type":[{"value":"2090-679X","type":"electronic"},{"value":"2090-6781","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4,22]]}}}