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Thirty piglets (21 \u00b1 2\u2009days\u2009old, 5.86 \u00b1 0.18\u2009kg body weight) were randomly divided into the control (a basal diet, saline injection), LPS (a basal diet), or LPS+HMB (a basal diet + 0.60% HMB\u2010Ca) group. After 15\u2009d of treatment with LPS and\/or HMB, blood and liver samples were obtained. The results showed that in LPS\u2010injected piglets, HMB supplementation ameliorated liver histomorphological abnormalities induced by LPS challenge. Compared to the control group, the activities of serum aspartate aminotransferase and alkaline phosphatase were increased in the LPS\u2010injected piglets (<jats:italic>P<\/jats:italic> &lt; 0.05). The LPS challenge also downregulated the mRNA expression of L\u2010PFK, ACO, L\u2010CPT\u20101, ICDH <jats:italic>\u03b2<\/jats:italic>, and AMPK<jats:italic>\u03b1<\/jats:italic>1\/2 and upregulated the mRNA expression of PCNA, caspase 3, TNF\u2010<jats:italic>\u03b1<\/jats:italic>, TLR4, MyD88, NOD1, and NF\u2010<jats:italic>\u03ba<\/jats:italic>B p65 (<jats:italic>P<\/jats:italic> &lt; 0.05). However, these adverse effects of the LPS challenge were reversed by HMB supplementation (<jats:italic>P<\/jats:italic> &lt; 0.05). These results indicate that HMB may exert protective effects against LPS\u2010induced liver injury, and the underlying mechanisms might involve the improvement of hepatic energy metabolism via regulating AMPK signaling pathway and the reduction of liver inflammation via modulating TLR4 and NOD signaling pathways.<\/jats:p>","DOI":"10.1155\/2021\/5546843","type":"journal-article","created":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T16:35:09Z","timestamp":1617381309000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Dietary Beta\u2010Hydroxy Beta\u2010Methyl Butyrate Supplementation Alleviates Liver Injury in Lipopolysaccharide\u2010Challenged 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