{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T21:03:42Z","timestamp":1740171822911,"version":"3.37.3"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,6,12]],"date-time":"2021-06-12T00:00:00Z","timestamp":1623456000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800070","2020CXA036","BPB-2020ZK"],"award-info":[{"award-number":["81800070","2020CXA036","BPB-2020ZK"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018534","name":"Medical Innovation Project of Fujian Province","doi-asserted-by":"crossref","award":["81800070","2020CXA036","BPB-2020ZK"],"award-info":[{"award-number":["81800070","2020CXA036","BPB-2020ZK"]}],"id":[{"id":"10.13039\/501100018534","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Health Special Fund Plan of Fujian Provincial Finance Department","award":["81800070","2020CXA036","BPB-2020ZK"],"award-info":[{"award-number":["81800070","2020CXA036","BPB-2020ZK"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2021,6,12]]},"abstract":"<jats:p>Objectives. To investigate the relationship between polymorphisms of calcitonin-related peptide gene II (beta-calcitonin gene-related peptide (\u03b2CGRP), CALCB) and serum CGRP levels in salivary adenoid cystic carcinoma. Materials and Methods. Using the polymerase chain reaction (PCR) technique, the full-length amplification and genotype analysis of CALCB genes were performed in 39 patients with adenoid cystic carcinoma of salivary gland and 158 normal controls. The gene frequencies of major genotype of CALCB in adenoid cystic carcinoma of salivary gland and normal control group were analyzed. Enzyme-linked immunosorbent assay (ELISA) was used to evaluate serum calcitonin gene-related peptide (CGRP) and its concentration of alpha and beta subtypes. Results. Univariate logistic regression analysis showed that the CALCB rs2839222 T\/T genotype was closely related to the occurrence of salivary adenoid cystic carcinoma, with a correlation coefficient of 3.89. Conclusions. The serum CGRP concentration in the salivary adenoid cystic carcinoma group was 1.56 times that of the normal control group. The \u03b1CGRP subtype was significant, which was 3.02 times that of the normal control. The polymorphism of \u03b2CGRP gene is associated with genetic susceptibility to salivary adenoid cystic carcinoma, and serum CGRP and \u03b2CGRP can be used as novel markers of salivary adenoid cystic carcinoma.<\/jats:p>","DOI":"10.1155\/2021\/5546858","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T22:50:07Z","timestamp":1623711007000},"page":"1-5","source":"Crossref","is-referenced-by-count":2,"title":["CALCB rs3829222 T\/T Genotype and Low Expression of CALCB Are High-Risk Factors for Adenoid Cystic Carcinoma of Salivary Gland"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2455-6164","authenticated-orcid":true,"given":"Chaobin","family":"Dai","sequence":"first","affiliation":[{"name":"School and Hospital of Stomatology, Fujian Medical University, No. 246, Yangqiao Middle Road, Gulou District, Fuzhou, Fujian Province 350000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6974-0611","authenticated-orcid":true,"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[{"name":"School and Hospital of Stomatology, Fujian Medical University, No. 246, Yangqiao Middle Road, Gulou District, Fuzhou, Fujian Province 350000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunyang","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Oral Maxillo-Facial Surgery, The First Affiliated Hospital of Fujian Medical University, No. 20 Chazhong Road, Fuzhou, Fujian Province 350000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1766-9395","authenticated-orcid":true,"given":"Qicai","family":"Liu","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, The First Affiliated Hospital of Fujian Medical University, No. 20 Chazhong Road, Fuzhou, Fujian Province 350000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feiguang","family":"Wu","sequence":"additional","affiliation":[{"name":"Standardized Training Base, The First Affiliated Hospital of Fujian Medical University, No. 20 Chazhong Road, Fuzhou, Fujian Province 350000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4100-6401","authenticated-orcid":true,"given":"Xiaoting","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Respiratory, 1st Affiliated Hospital, Fujian Medical University, Fuzhou 350004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4343-3207","authenticated-orcid":true,"given":"Kai","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, The First Affiliated Hospital of Fujian Medical University, No. 20 Chazhong Road, Fuzhou, Fujian Province 350000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1079-6607","authenticated-orcid":true,"given":"Xiaofeng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Oral Maxillo-Facial Surgery, The First Affiliated Hospital of Fujian Medical University, No. 20 Chazhong Road, Fuzhou, Fujian Province 350000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12860"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2020.104997"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.20-0242"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-042617-053158"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2013.03.006"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1111\/febs.14325"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.32"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2014.00023"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-018-0832-8"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1007\/s10194-009-0110-x"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.2174\/0929867325666180914115416"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-018-0927-2"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-2042.2001.00250.x"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1987.126"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.14670\/HH-16.1073"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-015-0630-8"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00034.2013"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2017.5554"},{"key":"19","first-page":"153","article-title":"The molecular genetics of lung cancer","volume":"37","author":"D. 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