{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:57:50Z","timestamp":1791493070562,"version":"4.3.4"},"reference-count":44,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,9,18]],"date-time":"2021-09-18T00:00:00Z","timestamp":1631923200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funds for Tan Hualin Famous Doctors in Hubei Provincial Hospital of traditional Chinese Medicine"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Analytical Cellular Pathology"],"published-print":{"date-parts":[[2021,9,18]]},"abstract":"<jats:p>Oxidative stress-induced neuronal damage is a main cause of ischemia\/reperfusion injury. Curcumin (Cur), the principal constituent extracted from dried rhizomes of Curcuma longa L. (turmeric), exhibits excellent antioxidant effects. Previous studies have indicated that miR-1287-5p was downregulated in patients with ischemic stroke. Additionally, we predicted that Lon Peptidase 2, Peroxisomal (LONP2), which is involved in oxidative stress regulation, is targeted by miR-1287-5p. The aim of the current study is to investigate the effect of Cur on ischemia\/reperfusion damage and its underlying mechanism. To mimic ischemia\/reperfusion damage environment, SH-SY5Y cells were subjected to oxygen-glucose-deprivation\/reperfusion (OGD\/R). OGD\/R treatment downregulated miR-1287-5p and upregulated LONP2 in SH-SY5Y cells, but Cur alleviated OGD\/R-induced oxidative damage and reversed the effect of OGD\/R on the expression of miR-1287-5p and LONP2. Furthermore, we confirmed the interactive relationship between miR-1287-5p and LONP2 (negative regulation). We revealed that miR-1287-5p overexpression alleviated OGD\/R-induced oxidative damage alleviation, similar to the effect of Cur. MiR-1287-5p inhibition accentuated OGD\/R-induced oxidative damage in SH-SY5Y cells, which was reversed by Cur. The expression of LONP2 in OGD\/R-treated SH-SY5Y cells was decreased by miR-1287-5p overexpression and increased by miR-1287-5p inhibition, and Cur counteracted the increase in LONP2 expression induced by miR-1287-5p inhibition. In conclusion, we suggest that Cur alleviates OGD\/R-induced oxidative damage in SH-SY5Y cells by regulating the miR-1287-5p\/LONP2 axis. The findings provide a theoretical basis for the clinical application of curcumin.<\/jats:p>","DOI":"10.1155\/2021\/5548706","type":"journal-article","created":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T22:50:45Z","timestamp":1632178245000},"page":"1-12","source":"Crossref","is-referenced-by-count":17,"title":["Curcumin Alleviates Oxygen-Glucose-Deprivation\/Reperfusion-Induced Oxidative Damage by Regulating miR-1287-5p\/LONP2 Axis in SH-SY5Y Cells"],"prefix":"10.1155","volume":"2021","author":[{"given":"Teng","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Traditional Chinese Medicine Encephalopathy, Hubei Provincial Hospital Traditional Chinese Medicine, Wuhan 430074, China"},{"name":"Department of Traditional Chinese Medicine Encephalopathy, Hubei Province Traditional Chinese Medicine Research Institute, Wuhan 430074, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine Encephalopathy, Hubei Provincial Hospital Traditional Chinese Medicine, Wuhan 430074, China"},{"name":"Department of Traditional Chinese Medicine Encephalopathy, Hubei Province Traditional Chinese Medicine Research Institute, Wuhan 430074, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueqing","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine Encephalopathy, Hubei Provincial Hospital Traditional Chinese Medicine, Wuhan 430074, China"},{"name":"Department of Traditional Chinese Medicine Encephalopathy, Hubei Province Traditional Chinese Medicine Research Institute, Wuhan 430074, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8214-3974","authenticated-orcid":true,"given":"Yanbing","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine Encephalopathy, Hubei Provincial Hospital Traditional Chinese Medicine, Wuhan 430074, China"},{"name":"Department of Traditional Chinese Medicine Encephalopathy, Hubei Province Traditional Chinese Medicine Research Institute, Wuhan 430074, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000485"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102547"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1515510"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)15692-4"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/370530"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13270"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1186\/s11658-019-0160-2"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.2741\/4727"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.2174\/1871527311312050015"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.09.013"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00028.2018"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-014-1437-x"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.3109\/09537104.2012.658107"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-016-0249-0"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2018.01.012"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201902956"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2017.11.012"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.11.098"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.921"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00233"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2019.104282"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102232"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.2174\/1567202616666191029113633"},{"key":"24","volume-title":"Study on the Regulation Network of circRNA-miRNA-mRNA Related to Ischemic Stroke","author":"Y. 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