{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:32:22Z","timestamp":1789014742205,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,7,24]],"date-time":"2021-07-24T00:00:00Z","timestamp":1627084800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2021,7,24]]},"abstract":"<jats:p>This study aimed to summarize the effectiveness and safety of acupuncture in the treatment of autism spectrum disorder (ASD) through literature analysis and evaluation. All studies were retrieved from various databases as follows: English databases, such as PubMed, Cochrane Library, Ovid, and Web of Science, and Chinese databases, such as China National Knowledge Infrastructure (CNKI), WanFang Data (WF), and Technology Periodical Database (VIP). The Cochrane Collaboration\u2019s Bias Risk Assessment Scale was used to assess the studies\u2019 risk of bias. The effects of acupuncture treatment for ASD were determined using the following indicators: childhood autism rating scale (CARS), autism behavior check list (ABC), Reynell developmental language scale (RDLS), and functional independence measure of children (WeeFIM). The risk map of bias of these studies\u2019 quality and the meta-analysis results of the indicators was prepared with RevMan 5.2 software. Finally, 16 studies were included, five of which were in English and 11 were in Chinese. The 16 studies included 1332 patients. The CARS results for subgroup analysis were as follows: acupuncture subgroup (MD\u2009=\u2009\u22122.65, 95% CI (\u22123.22, \u22122.07)) and acupuncture plus massage subgroup (MD\u2009=\u2009\u221210.35, 95% CI (\u221211.34, \u22129.36)). The ABC results were as follows: (MD\u2009=\u2009\u22126.70, 95% CI (\u22129.10, \u22124.29)). The analysis results of sensory, relating, language, body and object use, and social\/self-help in the subitems of ABC were as follows: sensory (MD\u2009=\u2009\u22122.67, 95% CI (\u22122.90, \u22122.44)), relating (MD\u2009=\u2009\u22123.28, 95% CI (\u22123.55, \u22123.02)), language (MD\u2009=\u2009\u22122.45, 95% CI (\u22122.73, \u22122.16)), body and object use (MD\u2009=\u2009\u22121.19, 95% CI (\u22121.38, \u22121.00)), and social\/self-help (MD\u2009=\u2009\u22122.09, 95% CI (\u22122.30, \u22121.89)). For the analysis results of comprehension and expression ages in the subitems of RDLS, the comprehension age results were as follows: (MD\u2009=\u20090.08, 95% CI (\u22120.06, 0.22), P\u2009=\u20090.27). Those of expression age were as follows: (MD\u2009=\u20090.15, 95% CI (0.04, 0.26), <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.009<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). The WeeFIM results were as follows: (MD\u2009=\u20093.70, 95% CI (2.38, 5.02)). This study suggested that acupuncture could effectively treat ASD. However, acupuncture methods and prescriptions at this stage remain heterogeneous, and acupuncture treatment operations require standardization. Studies using rigorous and standard research designs are needed to draw stronger conclusions about the advantages of using acupuncture to treat children and adolescents with ASD.<\/jats:p>","DOI":"10.1155\/2021\/5549849","type":"journal-article","created":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T18:35:09Z","timestamp":1627324509000},"page":"1-16","source":"Crossref","is-referenced-by-count":12,"title":["Clinical Randomized Controlled Study of Acupuncture Treatment on Children with Autism Spectrum Disorder (ASD): A Systematic Review and Meta-Analysis"],"prefix":"10.1155","volume":"2021","author":[{"given":"Lei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen 518107, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Lin","family":"Peng","sequence":"additional","affiliation":[{"name":"Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430000, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Qiang","family":"Qiao","sequence":"additional","affiliation":[{"name":"School of Education and Psychology, University of Jinan, Jinan 250000, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Ming","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Wei Zhong Children\u2019s Rehabilitation Center, Jinan 250000, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-Wen","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Wei Zhong Children\u2019s Rehabilitation Center, Jinan 250000, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Education and Psychology, University of Jinan, Jinan 250000, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-Ge","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Education and Psychology, University of Jinan, Jinan 250000, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Ying","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Education and Psychology, University of Jinan, Jinan 250000, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Zhong","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Wei Zhong Children\u2019s Rehabilitation Center, Jinan 250000, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7292-366X","authenticated-orcid":true,"given":"Pu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen 518107, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"03","key":"1","first-page":"289","article-title":"Guidelines for diagnosis, treatment and rehabilitation of childhood autism (health affairs office of the medical affairs Bureau [2010] no. 123)","volume":"19","year":"2011","journal-title":"Chinese Journal of Child Health Care"},{"key":"2","first-page":"59","article-title":"The trends in the development of autism diagnosis and service\u2014\u2014a prospect of the fifth edition of the draft \u201cdiagnostic and statistical manual of mental disorders","volume":"8","author":"J. 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