{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:01:38Z","timestamp":1767168098701,"version":"build-2238731810"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T00:00:00Z","timestamp":1620086400000},"content-version":"vor","delay-in-days":123,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province","doi-asserted-by":"publisher","award":["LH2020H007"],"award-info":[{"award-number":["LH2020H007"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81273174"],"award-info":[{"award-number":["81273174"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30671803"],"award-info":[{"award-number":["30671803"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n                    <jats:italic>Introduction<\/jats:italic>\n                    . Microribonucleic acids (miRNAs) have short (approximately 18 to 25) nucleotides and are evolutionarily conserved and endogenously expressed RNAs belonging to a family of noncoding RNA molecules. miRNA\u2010373 regulates cell proliferation, migration, apoptosis, invasion, and repairing damaged DNA after hypoxia stress. Neonatal hypoxic\u2013ischemic encephalopathy (HIE) refers to perinatal asphyxia caused by partial or complete hypoxia, reduced or suspended cerebral blood flow, and fetal or neonatal brain damage. We aim to investigate the relationship between miRNA\u2010373 and HIF\u20101\n                    <jats:italic>\u03b1<\/jats:italic>\n                    , between miRNA\u2010373 MMP\u20109, and between miRNA\u2010373 VEGF in the occurrence and development of HIE.\n                    <jats:italic>Methods<\/jats:italic>\n                    . Human (children) samples were divided into four groups (\n                    <jats:italic>n<\/jats:italic>\n                    = 15 in each group) according to HIE severity. The patient group was divided into middle, moderate, and severe HIE groups. The control group included healthy children or children with nonneurological diseases. The expressions of miRNA\u2010373, HIF\u20101\n                    <jats:italic>\u03b1<\/jats:italic>\n                    , MMP\u20109, and VEGF were assayed in the serum samples.\n                    <jats:italic>Results<\/jats:italic>\n                    . Our study showed a strong relationship between miRNA\u2010373 and HIF\u20101\n                    <jats:italic>\u03b1<\/jats:italic>\n                    , between miRNA\u2010373 and MMP\u20109, and between miRNA\u2010373 and VEGF. The expression levels of miRNA\u2010373, HIF\u20101\n                    <jats:italic>\u03b1<\/jats:italic>\n                    , MMP\u20109, and VEGF in the HIE groups were much higher than those of the control group.\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . The increased change in miRNA\u2010373 expression has a certain diagnostic significance on neonatal HIE. In the occurrence and development of HIE, miRNA\u2010373 is positively correlated with HIF\u20101\n                    <jats:italic>\u03b1<\/jats:italic>\n                    , MMP\u20109, and VEGF.\n                  <\/jats:p>","DOI":"10.1155\/2021\/5553486","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T15:41:33Z","timestamp":1620142893000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["[Retracted] Experimental Study on the Correlation between miRNA\u2010373 and HIF\u20101\u03b1, MMP\u20109, and VEGF in the Development of 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