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Dysphagia and odynophagia are common presenting symptoms; however, upper gastrointestinal bleeding (UGIB) associated with esophageal involvement of PV without a history of mucosal blistering is extremely uncommon. We present a case of esophageal involvement of PV associated with active UGIB that was diagnosed on endoscopic evaluation. This case illustrated the importance of early endoscopy to identify the esophageal involvement of PV especially in patients with preexisting disease who present with gastrointestinal symptoms such as dysphagia, odynophagia, and hematemesis. Early recognition of esophageal involvement of PV and initiation of corticosteroid and\/or immunosuppressant therapy may improve the outcome of the disease.<\/jats:p>","DOI":"10.1155\/2021\/5555961","type":"journal-article","created":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T19:21:20Z","timestamp":1616181680000},"page":"1-5","source":"Crossref","is-referenced-by-count":3,"title":["Esophageal Pemphigus Vulgaris: A Rare Etiology of Upper Gastrointestinal Hemorrhage"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7945-2197","authenticated-orcid":true,"given":"Jennifer Rose F.","family":"Del Castillo","sequence":"first","affiliation":[{"name":"Department of Medicine, MedStar Union Memorial Hospital, Baltimore, MD 21218, USA"},{"name":"MedStar Good Samaritan Hospital, Baltimore, MD 21239, USA"},{"name":"MedStar Franklin Square Medical Center, Baltimore, MD 21237, USA"},{"name":"MedStar Harbor Hospital, Baltimore, MD 21225, 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