{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:09:56Z","timestamp":1762474196055,"version":"build-2065373602"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,4,24]],"date-time":"2021-04-24T00:00:00Z","timestamp":1619222400000},"content-version":"vor","delay-in-days":113,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Endocrinology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>\n                    <jats:italic>Introduction<\/jats:italic>\n                    . Parathyroidectomy is the curative treatment option in primary hyperparathyroidism (PHPT). The decrease of parathormone (PTH) by 50% or more from levels prior to surgery after excision predicts successful parathyroidectomy. Serum calcium is expected to return to normal within 24\u201372 hours after the surgery; however, nearly 10% have transient, persistent postoperative hypercalcemia. We present a case report of delayed calcium normalization after successful parathyroidectomy in a 38\u2010year\u2010old patient with PHPT.\n                    <jats:italic>Methods<\/jats:italic>\n                    . Parathyroidectomy was performed, with evidence of a decrease in PTH levels of more than 50% in the first 24 hours postoperatively compared to presurgical PTH; however, despite curative parathyroidectomy, a delayed calcium normalization was evidenced, with hypercalcemia persistence up to 120 hours postoperatively.\n                    <jats:italic>Results<\/jats:italic>\n                    . After the first month postoperatively, serum calcium remained normal. In conclusion, approximately 10% of patients with curative parathyroidectomy have transient, persistent postoperative hypercalcemia, which is more likely to occur in patients with higher preoperative serum calcium and PTH levels.\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . Persistent hypercalcemia after the first month postoperatively is related with persistent PHPT, highlighting the importance of calcium monitoring after parathyroidectomy to predict short\u2010term, medium\u2010term, and long\u2010term outcomes and prognosis.\n                  <\/jats:p>","DOI":"10.1155\/2021\/5556977","type":"journal-article","created":{"date-parts":[[2021,4,24]],"date-time":"2021-04-24T14:35:33Z","timestamp":1619274933000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Delayed Calcium Normalization after Successful Parathyroidectomy in Primary Hyperparathyroidism"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7053-7191","authenticated-orcid":false,"given":"Iv\u00e1n Emilio","family":"de la Cruz Rodr\u00edguez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4645-6332","authenticated-orcid":false,"given":"Elsy Sarah\u00ed","family":"Garc\u00eda Montesinos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4160-0494","authenticated-orcid":false,"given":"Mar\u00eda Fernanda","family":"Rodr\u00edguez-Delgado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2225-2925","authenticated-orcid":false,"given":"Guadalupe","family":"Vargas Ortega","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0373-6641","authenticated-orcid":false,"given":"Lourdes Balc\u00e1zar","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9601-5204","authenticated-orcid":false,"given":"Victoria Mendoza","family":"Zubieta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2396-6142","authenticated-orcid":false,"given":"Victor Hern\u00e1ndez","family":"Avenda\u00f1o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6924-2209","authenticated-orcid":false,"given":"Baldomero Gonz\u00e1lez","family":"Virla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,24]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2016.2310"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2020.101514"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-01225"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-4022"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-016-3716-2"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5190-7"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2019.34.4.327"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02067339"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2727.66700"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2020.05.049"}],"container-title":["Case 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