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Pregnancy maintenance depends on the formation of normal placentas accompanied by trophoblast invasion and vascular remodeling. Various types of cells, such as trophoblasts, endothelial cells, immune cells, mesenchymal stem cells (MSCs), and adipocytes, mediate cell\u2010to\u2010cell interactions through soluble factors to maintain normal placental development. Extracellular vesicles (EVs) are diverse nanosized to microsized membrane\u2010bound particles released from various cells. EVs contain tens to thousands of different RNA, proteins, small molecules, DNA fragments, and bioactive lipids. EV\u2010derived microRNAs (miRNAs) and proteins regulate inflammation and trophoblast invasion in the placental microenvironment. Maternal\u2010fetal communication through EV can regulate the key signaling pathways involved in pregnancy maintenance, from implantation to immune regulation. Therefore, EVs and the encapsulating factors play important roles in pregnancy, some of which might be potential biomarkers. <jats:italic>Conclusion<\/jats:italic>. In this review, we have summarized published studies about the EVs in the placentation and pregnancy\u2010related diseases. By summarizing the role of EVs and their delivering active molecules in pregnancy\u2010related diseases, it provides novel insight into the diagnosis and treatment of diseases.<\/jats:p>","DOI":"10.1155\/2021\/5558048","type":"journal-article","created":{"date-parts":[[2021,6,19]],"date-time":"2021-06-19T14:20:19Z","timestamp":1624112419000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Role of Extracellular Vesicles in Placental Inflammation and Local Immune 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