{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T15:09:17Z","timestamp":1777561757988,"version":"3.51.4"},"reference-count":87,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,6,5]],"date-time":"2021-06-05T00:00:00Z","timestamp":1622851200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Commission Scientific Research Project of Hunan","award":["C2019164"],"award-info":[{"award-number":["C2019164"]}]},{"name":"Commission Scientific Research Project of Hunan","award":["2018B030334001"],"award-info":[{"award-number":["2018B030334001"]}]},{"name":"Commission Scientific Research Project of Hunan","award":["2020JJ4784"],"award-info":[{"award-number":["2020JJ4784"]}]},{"name":"Commission Scientific Research Project of Hunan","award":["81501163"],"award-info":[{"award-number":["81501163"]}]},{"name":"Commission Scientific Research Project of Hunan","award":["81270019"],"award-info":[{"award-number":["81270019"]}]},{"name":"Commission Scientific Research Project of Hunan","award":["81971258"],"award-info":[{"award-number":["81971258"]}]},{"name":"Commission Scientific Research Project of Hunan","award":["81771447"],"award-info":[{"award-number":["81771447"]}]},{"name":"Commission Scientific Research Project of Hunan","award":["2016YFC1307100"],"award-info":[{"award-number":["2016YFC1307100"]}]},{"name":"Key-Area Research and Development Program of Guangdong Province","award":["C2019164"],"award-info":[{"award-number":["C2019164"]}]},{"name":"Key-Area Research and Development Program of Guangdong Province","award":["2018B030334001"],"award-info":[{"award-number":["2018B030334001"]}]},{"name":"Key-Area Research and Development Program of Guangdong Province","award":["2020JJ4784"],"award-info":[{"award-number":["2020JJ4784"]}]},{"name":"Key-Area Research and Development Program of Guangdong Province","award":["81501163"],"award-info":[{"award-number":["81501163"]}]},{"name":"Key-Area Research and Development Program of Guangdong Province","award":["81270019"],"award-info":[{"award-number":["81270019"]}]},{"name":"Key-Area Research and Development Program of Guangdong Province","award":["81971258"],"award-info":[{"award-number":["81971258"]}]},{"name":"Key-Area Research and Development Program of Guangdong Province","award":["81771447"],"award-info":[{"award-number":["81771447"]}]},{"name":"Key-Area Research and Development Program of Guangdong Province","award":["2016YFC1307100"],"award-info":[{"award-number":["2016YFC1307100"]}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["C2019164"],"award-info":[{"award-number":["C2019164"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2018B030334001"],"award-info":[{"award-number":["2018B030334001"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2020JJ4784"],"award-info":[{"award-number":["2020JJ4784"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["81501163"],"award-info":[{"award-number":["81501163"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["81270019"],"award-info":[{"award-number":["81270019"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["81971258"],"award-info":[{"award-number":["81971258"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["81771447"],"award-info":[{"award-number":["81771447"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2016YFC1307100"],"award-info":[{"award-number":["2016YFC1307100"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["C2019164"],"award-info":[{"award-number":["C2019164"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2018B030334001"],"award-info":[{"award-number":["2018B030334001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2020JJ4784"],"award-info":[{"award-number":["2020JJ4784"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81501163"],"award-info":[{"award-number":["81501163"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270019"],"award-info":[{"award-number":["81270019"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971258"],"award-info":[{"award-number":["81971258"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771447"],"award-info":[{"award-number":["81771447"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2016YFC1307100"],"award-info":[{"award-number":["2016YFC1307100"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key R&D Program of China","award":["C2019164"],"award-info":[{"award-number":["C2019164"]}]},{"name":"National Key R&D Program of China","award":["2018B030334001"],"award-info":[{"award-number":["2018B030334001"]}]},{"name":"National Key R&D Program of China","award":["2020JJ4784"],"award-info":[{"award-number":["2020JJ4784"]}]},{"name":"National Key R&D Program of China","award":["81501163"],"award-info":[{"award-number":["81501163"]}]},{"name":"National Key R&D Program of China","award":["81270019"],"award-info":[{"award-number":["81270019"]}]},{"name":"National Key R&D Program of China","award":["81971258"],"award-info":[{"award-number":["81971258"]}]},{"name":"National Key R&D Program of China","award":["81771447"],"award-info":[{"award-number":["81771447"]}]},{"name":"National Key R&D Program of China","award":["2016YFC1307100"],"award-info":[{"award-number":["2016YFC1307100"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neural Plasticity"],"published-print":{"date-parts":[[2021,6,5]]},"abstract":"<jats:p>Objectives. Previous researches have demonstrated that abnormal functional connectivity (FC) is associated with the pathophysiology of bipolar disorder (BD). However, inconsistent results were obtained due to different selections of regions of interest in previous researches. This study is aimed at examining voxel-wise brain-wide functional connectivity (FC) alterations in the first-episode, drug-naive patient with BD in an unbiased way. Methods. A total of 35 patients with BD and 37 age-, sex-, and education-matched healthy controls underwent resting-state functional magnetic resonance imaging (rs-fMRI). Global-brain FC (GFC) was applied to analyze the image data. Support vector machine (SVM) was adopted to probe whether GFC abnormalities could be used to identify the patients from the controls. Results. Patients with BD exhibited increased GFC in the left inferior frontal gyrus (LIFG), pars triangularis and left precuneus (PCu)\/superior occipital gyrus (SOG). The left PCu belongs to the default mode network (DMN). Furthermore, increased GFC in the LIFG, pars triangularis was positively correlated with the triglycerides (TG) and low-density lipoprotein cholesterol (LDL-C) and negatively correlated with the scores of the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) coding test and Stroop color. Increased GFC values in the left PCu\/SOG can be applied to discriminate patients from controls with preferable sensitivity (80.00%), specificity (75.68%), and accuracy (77.78%). Conclusions. This study found increased GFC in the brain regions of DMN; LIFG, pars triangularis; and LSOG, which was associated with dyslipidemia and cognitive impairment in patients with BD. Moreover, increased GFC values in the left PCu\/SOG may be utilized as a potential biomarker to differentiate patients with BD from controls.<\/jats:p>","DOI":"10.1155\/2021\/5560453","type":"journal-article","created":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T21:39:04Z","timestamp":1623101944000},"page":"1-10","source":"Crossref","is-referenced-by-count":10,"title":["Increased Global-Brain Functional Connectivity Is Associated with Dyslipidemia and Cognitive Impairment in First-Episode, Drug-Naive Patients with Bipolar Disorder"],"prefix":"10.1155","volume":"2021","author":[{"given":"Pan","family":"Pan","sequence":"first","affiliation":[{"name":"National Clinical Research Center on Mental Disorders and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Qiu","sequence":"additional","affiliation":[{"name":"National Clinical Research Center on Mental Disorders and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziwei","family":"Teng","sequence":"additional","affiliation":[{"name":"National Clinical Research Center on Mental Disorders and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sujuan","family":"Li","sequence":"additional","affiliation":[{"name":"National Clinical Research Center on Mental Disorders and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Huang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center on Mental Disorders and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Xiang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center on Mental Disorders and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Tang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center on Mental Disorders and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jindong","family":"Chen","sequence":"additional","affiliation":[{"name":"National Clinical Research Center on Mental Disorders and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chujun","family":"Wu","sequence":"additional","affiliation":[{"name":"National Clinical Research Center on Mental Disorders and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Jin","sequence":"additional","affiliation":[{"name":"National Clinical Research Center on Mental Disorders and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bolun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Tianjin Medical University General Hospital, Tianjin 300000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6571-7024","authenticated-orcid":true,"given":"Haishan","family":"Wu","sequence":"additional","affiliation":[{"name":"National Clinical Research Center on Mental Disorders and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1626-2465","authenticated-orcid":true,"given":"Wenbin","family":"Guo","sequence":"additional","affiliation":[{"name":"National Clinical Research Center on Mental Disorders and Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China"},{"name":"Department of Psychiatry, The Third People's Hospital of Foshan, Foshan, Guangdong 528000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12796"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2013.07.004"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/ajad.12713"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2011.03.003"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-020-1130-0"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(14)70004-7"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1177\/0091217417749786"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2004.04.010"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2015.04.004"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1097\/NMD.0000000000000720"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2004.00111.x"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.11m07471"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.nurx.2005.12.009"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2016.04.052"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.07.031"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2015.12.005"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12469"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1111\/bdi.12047"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.170175"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.04.054"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32633"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbw099"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.08.063"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1177\/0004867417745996"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/16.10.906"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2019.04.017"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1007\/s12021-016-9299-4"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5062-08.2009"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.890"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2016.2600248"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145714000674"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2019.04.099"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22663"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2016.0454"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038131"},{"key":"36","volume-title":"Applied Multiple Regression\/Correlation Analysis For The Behavioral Sciences","author":"J. Cohen","year":"2003"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.01358"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00145"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2019.09.003"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6611703"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2020.572693"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1186\/s12911-017-0559-5"},{"key":"43","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4757-3264-1","volume-title":"The Nature of Statistical Learning Theory","author":"V. Vapnik","year":"2000"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1206-1565"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1016\/j.asoc.2016.02.009"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1145\/1961189.1961199"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1007\/s12293-015-0153-2"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1007\/s11571-017-9431-7"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1037\/0882-7974.17.1.85"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbv062"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.09.033"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2004.02420.x"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1037\/emo0000447"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1038\/nn0305-261"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws059"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000489"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsaa014"},{"key":"58","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511526831","volume-title":"Disorders of Affect Regulation: Alexithymia in Medical and Psychiatric Illness","author":"G. Taylor","year":"1997"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2017.04.065"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.5455\/apd.188358"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2007.06.014"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2017.12.037"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2018.11.016"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2013.07.007"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-12-106"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2015.04.010"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2009.12.004"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-13-04275.1996"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00108-7"},{"key":"70","doi-asserted-by":"publisher","DOI":"10.1162\/jocn_a_01426"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.07.015"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.05.059"},{"key":"73","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandl.2016.02.003"},{"key":"74","doi-asserted-by":"publisher","DOI":"10.1159\/000110726"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.03.067"},{"key":"76","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-011-0301-2"},{"key":"77","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9061846"},{"key":"78","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2019.134596"},{"key":"79","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2005.00234.x"},{"key":"80","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2019.00070"},{"key":"81","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.01.016"},{"key":"82","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.10.033"},{"key":"83","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20128"},{"key":"84","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12603"},{"key":"85","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20252"},{"key":"86","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.14663"},{"key":"87","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2014.02.033"}],"container-title":["Neural Plasticity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/np\/2021\/5560453.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/np\/2021\/5560453.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/np\/2021\/5560453.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T21:39:20Z","timestamp":1623101960000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/np\/2021\/5560453\/"}},"subtitle":[],"editor":[{"given":"Toshiharu","family":"Nakai","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,6,5]]},"references-count":87,"alternative-id":["5560453","5560453"],"URL":"https:\/\/doi.org\/10.1155\/2021\/5560453","relation":{},"ISSN":["1687-5443","2090-5904"],"issn-type":[{"value":"1687-5443","type":"electronic"},{"value":"2090-5904","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6,5]]}}}