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Existing studies have shown that abnormal miR\u2010143\u20103p expression was observed in both RA patients and arthritis animals, which can participate in osteoclast differentiation, and mitogen\u2010activated protein kinase (MAPK) signaling pathway was closely related to osteoclast differentiation. The primary objective of the current study was to determine the role of miR\u2010143\u20103p in the progression of osteoclast differentiation and its relationship with MAPK signaling pathways. The results showed that miR\u2010143\u20103p inhibited osteoclast differentiation and decreased the levels of M\u2010CSF and RANKL during osteoclast differentiation. miR\u2010143\u20103p inhibited the expression of MAPK signaling proteins, which is ERK1\/2 in the early stage and JNK in the later stage of osteoclast differentiation. It was also observed that MAPK inhibitors upregulated miR\u2010143\u20103p expression in osteoclast differentiation. Taken together, our results suggested that miR\u2010143\u20103p could inhibit the differentiation of osteoclast, which was related to inhibiting MAPK signaling pathways. This may provide a novel strategy for curing RA.<\/jats:p>","DOI":"10.1155\/2021\/5565973","type":"journal-article","created":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T19:05:27Z","timestamp":1630091127000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["miR\u2010143\u20103p Inhibits the Differentiation of Osteoclast Induced by Synovial Fibroblast and Monocyte Coculture in Adjuvant\u2010Induced Arthritic Rats"],"prefix":"10.1155","volume":"2021","author":[{"given":"Baoping","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengchen","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiyu","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueping","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8395-9783","authenticated-orcid":false,"given":"Lingling","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,27]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.111861"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.105900"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18102054"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-200305000-00016"},{"key":"e_1_2_10_5_2","first-page":"1235","article-title":"Influence of MAPK pathways on co-cultured osteoclasts differentiation and effects of Qingluotongbi granule on MAPK expressions","volume":"29","author":"Zhou L.","year":"2013","journal-title":"Chinese Journal of Immunology"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2015.07.005"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8010110"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2013.07.007"},{"key":"e_1_2_10_9_2","first-page":"715","article-title":"Comparison of abnormal expression of miRNAs in peripheral blood of rheumatoid arthritis patients and osteoclasts in rat and analysis of any miRNAs","volume":"5","author":"Yuan C.","year":"2017","journal-title":"Chinese Journal of Immunology"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1113\/ep087992"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.2174\/1874467213666200116113945"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-017-1346-5"},{"key":"e_1_2_10_13_2","first-page":"168","article-title":"Effects of Qingluotongbi granule on osteo-like cells induced by co-culturing synovial fibroblasts and monocytes","volume":"17","author":"Zhou L.","year":"2011","journal-title":"Chinese Journal of Immunology"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-014-9062-5"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2018.5907"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17060842"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.40039"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13402-017-0341-9"},{"key":"e_1_2_10_19_2","first-page":"51","article-title":"Study of Qingluo Tongbi compound treating rheumatoid arthritis based on miRNA network","volume":"32","author":"Zhu Y.","year":"2016","journal-title":"Chinese Journal of Immunology"},{"key":"e_1_2_10_20_2","volume-title":"Gene expression profile analysis of rheumatoid arthritis synovial cells and preliminary study of the pathogenesis. 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