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This study was aimed at evaluating the target genes of miR\u2010204 involved in the development and progression of common retinopathies such as glaucoma, retinoblastoma, and age\u2010related macular degeneration. In this study, three datasets related to retinopathies (GSE50195, GSE27276, and GSE97508) were selected from Gene Expression Omnibus. miR\u2010204 target genes were isolated from TargeScan. The shares between retinopathy and miR\u2010204 target genes were then categorized. Using Enrichr and STRING, we highlighted the signaling pathways and the relationships between the proteins. SHC1 events in ERBB2, adherent junction\u2019s interactions, NGF signaling via TRKA from the plasma membrane, IRF3\u2010mediated activation of type 1 IFN, pathways in upregulated genes and G0 and early G1, RORA\u2010activated gene expression, PERK\u2010regulated gene expression, adherent junction\u2019s interactions, and CREB phosphorylation pathways in downregulated genes were identified in glaucoma, retinoblastoma, and age\u2010related macular degeneration. WEE1, SMC2, HMGB1, RRM2, and POLA1 proteins were also observed to be involved in the progression and invasion of retinoblastoma; SLC24A2 and DTX4 in age\u2010related macular degeneration; and EPHB6, EFNB3, and SHC1 in glaucoma. Continuous bioinformatics analysis has shown that miR\u2010204 has a significant presence and expression in retinal tissue, and approximately 293 genes are controlled and regulated by miR\u2010204 in this tissue; also, target genes of miR\u2010204 have the potential to develop various retinopathies; thus, a study of related target genes can provide appropriate treatment strategies in the future.<\/jats:p>","DOI":"10.1155\/2021\/5568113","type":"journal-article","created":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T21:03:10Z","timestamp":1633381390000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Investigation of Key Signaling Pathways Associating miR\u2010204 and Common 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