{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:06:25Z","timestamp":1785855985088,"version":"3.56.0"},"reference-count":67,"publisher":"Wiley","license":[{"start":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T00:00:00Z","timestamp":1621900800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005595","name":"University of California","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Immunology"],"published-print":{"date-parts":[[2021,5,25]]},"abstract":"<jats:p>Selective IgM deficiency (SIgMD) and isolated collagenous gastritis are two independent rare disorders. Our purpose is to report the 1st case of SIgMD and isolated collagenous gastritis and collagenous gastritis that has transitioned to EBV\u2009+\u2009gastric adenocarcinoma. Gastric biopsy tissue was analyzed by EBV-related encoded RNA in situ hybridization assay. Subsets of CD4, CD8, T follicular helper cells (TFH), and members of the \u201cregulatory lymphocytes club\u201d were measured with multiple panels of monoclonal antibodies and isotype controls by multicolor flow cytometry. The patient was diagnosed with SIgMD (extremely low serum IgM 9\u2009mg\/dl and normal IgG and IgA and exclusion of secondary causes of low IgM). Soon after SIgMD diagnosis, the patient developed collagenous gastritis and, 8 years later, developed gastric adenocarcinoma that was positive for EBV. An extensive immunological analysis revealed reduced na\u00efve CD4 and CD8 effector memory T cells and increased na\u00efve and central memory CD8 T cells. Among the circulating follicular helper T cells (cTFH), TFH1 and TFH2 were increased whereas TFH17 was decreased. CD4 Treg cells and TFR cells were increased, whereas Breg and CD8 Treg were comparable to control. In conclusion, SIgMD may be associated with isolated collagenous gastritis, and collagenous gastritis may transition to EBV\u2009+\u2009gastric adenocarcinoma. A role of regulatory lymphocytes in gastric cancer is discussed.<\/jats:p>","DOI":"10.1155\/2021\/5574944","type":"journal-article","created":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T17:53:23Z","timestamp":1622051603000},"page":"1-8","source":"Crossref","is-referenced-by-count":5,"title":["Collagenous Gastritis in Primary Selective IgM Deficiency: Transition to EBV+ Gastric Adenocarcinoma"],"prefix":"10.1155","volume":"2021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0841-6580","authenticated-orcid":true,"given":"Tejal","family":"Narsai","sequence":"first","affiliation":[{"name":"Division of Basic and Clinical Immunology, University of California, Irvine, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7770-3519","authenticated-orcid":true,"given":"Houfen","family":"Su","sequence":"additional","affiliation":[{"name":"Division of Basic and Clinical Immunology, University of California, Irvine, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2559-2578","authenticated-orcid":true,"given":"David","family":"Braxton","sequence":"additional","affiliation":[{"name":"Hoag Hospital, Newport Beach, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7422-1453","authenticated-orcid":true,"given":"Sudhir","family":"Gupta","sequence":"additional","affiliation":[{"name":"Division of Basic and Clinical Immunology, University of California, Irvine, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.4.5579.583"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-017-0465-8"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-019-00641-4"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-013-8375-x"},{"key":"5","first-page":"55","article-title":"Comprehensive clinical and immunological features of 62 adult patients with selective primary IgM deficiency","volume":"8","author":"D. 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